Objective:To evaluate the diagnostic value of urinary microalbumin(U-MALB),serum complement C1q and cystatin C(CysC)in renal injury of chronic kidney disease(CKD).Method:The clinical data of 120 patients with CKD in various stages admitted to Yichun People's Hospital from January 2021 to December 2022 were retrospectively analyzed.According to the results of MDRD formula,they were divided into group A(stage Ⅰ mild injury,58 cases),group B(stage Ⅱ,stage Ⅲ moderate injury,43 cases)and group C(stage Ⅳ,stage Ⅴsevere injury,19 cases).Thirty healthy subjects who underwent physical examination in our hospital during the same period were selected as the control group,and the differences of U-MALB,serum CysC and complement C1q among the four groups were compared.The diagnostic efficacy of U-MALB,serum CysC and complement C1q alone and in combination in kidney injury in CKD was evaluated.Result:There were significant differences in U-MALB,serum CysC and complement C1q levels among the four groups(P<0.05).The Kappa value of U-MALB combined with serum CysC and complement C1q was 0.719 in patients with kidney injury in CKD,which was higher than 0.403,0.412 and 0.248 in U-MALB,serum CysC and complement C1q alone.The sensitivity and accuracy of combined detection were higher than those of U-MALB,serum CysC and complement C1q alone,the differences were statistically significant(P<0.05).Conclusion:The combined detection of U-MALB,serum CysC and complement C1q has high diagnostic value for kidney injury in CKD,and it is simple and economical,and can sensitively reflect kidney injury.
维普
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