Objective:To investigate the comfort and effectiveness of ultrasound-guided continuous fascia iliaca compartment block(UCFICB)in advanced analgesia in elderly patients with femoral neck fracture,and objectively evaluate its effects from the perspective of serum interleukin-6(IL-6)and brain-derived neurotrophic factor(BDNF).Method:A total of 60 patients undergoing unilateral total hip arthroplasty under general anesthesia were selected from Ganzhou People's Hospital from January to December 2022,the patients were divided into two groups by random number table method:experimental group(n=30,preemptive analgesia with ultrasound-guided continuous fascia iliaca compartment block)and control group(n=30,routine intravenous self-controlled analgesia).Pain perception,mental status,peripheral blood IL-6 and BDNF levels at different time points,and intraoperative opioid consumption were compared between the two groups.Result:There were no significant differences in visual analogue score(VAS)between the two groups immediately after admission and during exercise(P>0.05);24 and 48 h after surgery,VAS scores at rest and exercise in experimental group were lower than those in control group,the differences were statistically significant(P<0.05).The total consumption of Sufentanil and Remifentanil in experimental group were less than those in control group,the differences were statistically significant(P<0.05).There was no significant difference in MMSE score between the two groups at admission(P>0.05);24 and 72 h after surgery,MMSE scores in experimental group were higher than those in control group,the differences were statistically significant(P<0.05).Compared with the control group,the experimental group had lower levels of IL-6 and higher levels of BDNF in the postoperative and 24 h postoperative,the differences were statistically significant(P<0.05).Conclusion:The application of ultrasound-guided continuous fascia iliaca compartment block advanced analgesia in elderly patients with femoral neck fracture can alleviate perioperative pain,reduce the use of analgesic drugs,reduce perioperative inflammatory stress response,improve patients'cognition.
关键词
股骨颈骨折/超声引导/连续髂筋膜间隙阻滞/超前镇痛/白介素-6/脑源性神经营养因子
Key words
Femoral neck fracture/Ultrasonic guidance/Continuous fascia iliaca compartment block/Preemptive analgesia/IL-6/BDNF
维普
万方数据