Analysis of Risk Factors for Type 2 Diabetes Mellitus in Patients with Non-alcoholic Fatty Liver Disease and Observation of the Effect of Dulaglutide Therapy
Objective:To explore the risk factors of type 2 diabetes mellitus(T2DM)in patients with non-alcoholic fatty liver disease(NAFLD)and the effect of Dulaglutide therapy.Method:Clinical data of 150 patients with NAFLD admitted to Shangrao People's Hospital from January 2020 to October 2023 were retrospectively analyzed,and the patients were divided into T2DM group(n=45)and non-T2DM group(n=105)according to relevant criteria.Univariate analysis and multivariate logistic regression were used to analyze the risk factors of T2DM in NAFLD patients.At the same time,the effect of Dulaglutide treatment in T2DM group after 16 weeks was analyzed.Result:Body mass index,waist-to-hip ratio,genetic history of diabetes,fasting blood glucose,2 h postprandial blood glucose,insulin sensitivity index(ISI),homeostasis model assessment insulin resistance(HOMA-IR),triglyceride(TG),low density lipoprotein cholesterol(LDL-C),alanine transaminase(ALT),serum uric acid(SUA)levels in both groups were compared,the differences were statistically significant(P<0.05).Multivariate logistic regression analysis showed that waist-hip ratio,genetic history of diabetes,TG,HOMA-IR and SUA were the risk factors for T2DM in NAFLD patients(P<0.05).All 45 patients with NAFLD combined with T2DM successfully completed treatment,the total effective rate was 91.11%(41/45),and the total incidence of adverse reactions was 8.89%(4/45);after treatment,fasting blood glucose,2 h postprandial blood glucose,TG,LDL-C,ALT,HOMA-IR levels and liver fat attenuation parameters were all lower than those before treatment,and ISI was higher than that before treatment,the differences were statistically significant(P<0.05).Conclusion:NAFLD patients have a higher probability of T2DM,which is related to waist-to-hip ratio,genetic history of diabetes,TG,HOMA-IR,SUA and other factors.Meanwhile,Dulaglutide therapy can significantly improve glycolipid metabolism,insulin resistance and reduce liver fat.
万方数据
维普
