The Correlation between Thyroid Hormone Levels and HOMA-IR,Glucose Metabolism Disorders in Patients with Hyperthyroidism
Objective:To explore the correlation between thyroid hormone levels and insulin resistance,glucose metabolism disorders in patients with hyperthyroidism.Method:A total of 42 patients with hyperthyroidism admitted to First People's Hospital of Fuzhou from October 2022 to November 2023 were selected as the study group,and 42 healthy individuals who underwent health examinations at the same time were selected as the control group.The levels of thyroid hormones[thyroid stimulating hormone(TSH),free triiodothyronine(FT3),free thyroxine(FT4)],insulin resistance index(HOMA-IR),blood glucose levels[fasting blood glucose(FPG),glycated hemoglobin(HbA1c)]of two groups were detected and compared,and the relationship between thyroid hormone levels and insulin resistance and glucose metabolism disorders in patients with hyperthyroidism through Pearson correlation test was analyzed.Result:The TSH level in the study group was lower than that in the control group,while the levels of FT3,FT4,HOMA-IR,FPG and HbA1c were higher than those in the control group,with statistical significance(P<0.05).According to Pearson correlation analysis,TSH level in hyperthyroidism patients was negatively correlated with HOMA-IR,FPG and HbA1c levels(r<0,P<0.05);the levels of FT3 and FT4 were positively correlated with HOMA-IR,FPG and HbA1c levels(r>0,P<0.05).Conclusion:Thyroid hormone levels in patients with hyperthyroidism are related to insulin resistance and glucose metabolism dysfunction.With the imbalance of thyroid hormone levels,insulin resistance and glucose metabolism dysfunction worsen.
万方数据
维普
