Effect of Conformal Intensity Modulated Radiotherapy Synchronous Targeted Therapy on Tumor Markers in Patients with Nasopharyngeal Carcinoma
Objective:To investigate the effect of conformal intensity modulated radiotherapy synchronous targeted therapy in patients with nasopharyngeal carcinoma and its influence on tumor markers.Method:A total of 60 patients with nasopharyngeal carcinoma admitted to Department of Oncology Ⅰ,People's Hospital of Yangjiang from March 2020 to March 2023 were selected as subjects and divided into two groups by envelope method,with 30 cases in each group.The control group received conformal intensity modulated radiotherapy,and the observation group was combined with targeted therapy on the basis of the control group.Objective response rate(ORR),the levels of tumor markers,vascular endothelial growth factor(VEGF),thrombospondin-1(TSP-1),transforming growth factor-β1(TGF-β1),interleukin-6(IL-6),vascular endothelial growth factor receptor-2(VEGFR-2)and incidence of toxic side effects were compared between the two groups.Result:The ORR of observation group was 83.33%,which was higher than 50.00%of control group,the difference was statistically significant(P<0.05).The tumor markers were decreased in both groups after intervention,and the levels of carcinoembryonic antigen(CEA),squamous cell carcinoma antigen(SCCA)and cyto-keratin 19 fragment antigen 21-1(Cyfra21-1)in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).The biochemical indexes of both groups were improved after intervention,the levels of VEGF,VEGFR-2,TGF-β1 and IL-6 in observation group were lower than those in control group,and TSP-1 was higher than that in control group,the differences were statistically significant(P<0.05).There was no significant difference in the incidence of toxic side effects between the two groups(P>0.05).Conclusion:Conformal intensity modulated radiotherapy synchronous targeted therapy in patients with nasopharyngeal carcinoma can improve ORR,reduce the levels of tumor markers,VEGF,TGF-β1,IL-6 and VEGFR-2,without increasing the incidence of toxic side effects.
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