Observation on the Effect of Low-dose Progestin Combined with Levonorgestrel Intrauterine System in the Treatment of Endometrial Hyperplasia
Objective:To investigate the efficacy of low-dose progestin combined with levonorgestrel intrauterine system(Mirena)in the treatment of endometrial hyperplasia(EH).Method:A total of 92 patients with EH treated at Rushan Traditional Chinese Medicine Hospital from May 2020 to March 2023 were selected,and were divided into a control group(Mirena)and a study group(combined with low-dose progestin)by random number table method,with 46 patients in each group.Clinical indicators(endometrial thickness,menstrual duration),sex hormone levels[luteinizing hormone(LH),follicle stimulating hormone(FSH)],vascular endothelial growth factor(VEGF),clinical efficacy,phosphate and tensin homology deleted on chromosome(PTEN),P16 protein,and epithelial membrane protein 2(EMP2)were compared between the two groups.Result:After treatment,the thickness of the endometrium in both groups were decreased compared to before treatment,and the duration of menstruation were shortened compared to before treatment,the above indicators in the study group were better than those in the control group,the differences were statistically significant(P<0.05).After treatment,LH,FSH,and VEGF in both groups were decreased compared to before treatment,and those in the study group were lower than those in the control group,the differences were statistically significant(P<0.05).The total effective rate of the control group was lower than that of the study group,the difference was statistically significant(P<0.05).After treatment,the levels of P16 protein and PTEN were increased in both groups,while EMP2 were decreased compared to before treatment,the above indicators in the study group were better than those in the control group,the differences were statistically significant(P<0.05).Conclusion:Treatment with low-dose progestin combined with Mirena in EH patients can reduce endometrial thickness,improve vascular endothelium and sex hormone levels,and regulate P16 protein,PTEN,and EMP2.
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