Influence of Antiviral Treatment Time on CD4+T Lymphocyte Count and HIV Viral Load in HIV/AIDS Patients
Objective:To explore the effects of antiviral treatment time on CD4+T lymphocyte count and HIV viral load in human immunodeficiency virus(HIV)/acquired immunodeficiency syndrome(AIDS)patients.Method:Clinical data of 200 HIV/AIDS patients admitted to Xinyu People's Hospital from April 2018 to April 2023 were retrospectively collected.According to the antiviral treatment time after diagnosis,they were divided into group A(treatment for 1 year,n=30),group B(treatment for 2 years,n=26),group C(treatment for 3 years,n=45)and group D(after 4 years of treatment,n=99).HIV viral load and CD4+T lymphocyte count after treatment were compared among all groups,and the relationship between antiviral treatment time and CD4+T lymphocyte count,HIV viral load was analyzed.Multiple linear regression was used to analyze the influencing factors of CD4+T lymphocyte count changes after HIV/AIDS antiviral treatment.Result:The CD4+T lymphocyte count of group D was higher than that of group A,group B and group C,and the CD4+T lymphocyte count of group C was higher than that of group A and group B,and the CD4+T lymphocyte count of group B was higher than that of group A,the differences were statistically significant(P<0.05).There was no significant difference in HIV viral load among the four groups(P>0.05).The CD4+T lymphocyte counts of HIV/AIDS patients with different genders,baseline CD4+T lymphocyte counts,and WHO clinical stages after antiviral treatment were compared,the differences were statistically significant(P<0.05).Multiple linear regression analysis showed that baseline CD4+T lymphocyte count and treatment time were factors influencing the change of CD4+T lymphocyte count in HIV/AIDS patients after antiviral treatment(P<0.05).Conclusion:The longer the duration of antiviral treatment,the more obvious the improvement effect of CD4+T lymphocyte count in HIV/AIDS patients.Baseline CD4+T lymphocyte count and treatment time are the influencing factors for the change of CD4+T lymphocyte count in HIV/AIDS patients after antiviral treatment.
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