Diagnostic Value of Inflammatory Factors and T Lymphocyte Subsets on Patients with Community-acquired Pneumonia in Different Age Groups
Objective:To explore the diagnostic value of inflammatory factors and T lymphocyte subsets on patients with community-acquired pneumonia(CAP)in different age groups.Method:A total of 100 patients with CAP treated and diagnosed in Department of Respiratory and Critical Care Medicine of Shangrao People's Hospital were selected as case group,and 60 healthy subjects with physical examination were included in control group.The two groups were divided into young group(18-44 years old),middle-aged group(45-59 years old)and elderly group(≥60 years old)according to different ages.The levels of inflammatory factors[white blood cell(WBC)count,neutrophil/lymphocyte ratio(NLR),C reactive protein(CRP),procalcitonin(PCT),interleukin-6(IL-6)]and T lymphocyte subsets(CD3+,CD4+and CD4+/CD8+)in the same age group were compared between groups.Receiver operating characteristic(ROC)curve was drawn to analyze the value of the above inflammatory factors and T lymphocyte subsets alone and in combination in the diagnosis of CAP patients in different age groups.Result:Compared with young group,middle-aged group and elderly group in control group,the levels of WBC,NLR,CRP,PCT and IL-6 in case group were higher,with statistical differences(P<0.05).In case group,the levels of WBC,NLR,PCT and CRP in young group and middle-aged group were higher than those in elderly group,while the levels of IL-6 were lower than that in elderly group,the differences were statistically significant(P<0.05).Compared with young group,middle-aged group and elderly group in the same age group of control group,the CD3+levels of the young group,middle-aged group and elderly group in case group were higher,while the CD4+and CD4+/CD8+levels were lower,with statistical differences(P<0.05).In case group,the levels of CD3+in young group and middle-aged group were lower,while the levels of CD4+and CD4+/CD8+were higher compared with those in elderly group,with statical differences(P<0.05).ROC curve showed that the areas under the curves of the combination of inflammatory factors and T lymphocyte subsets in young and middle-aged and elderly CAP were 0.937 and 0.912 respectively.Conclusion:WBC,NLR,CRP,PCT,IL-6,CD3+,CD4+and CD4+/CD8+in CAP patients of different age groups have more significant abnormal changes compared with healthy people,and the above indicators in elderly CAP patients are also different from those in young and middle-aged CAP patients.The above indicators can be used to diagnose CAP patients of different age groups.
Community-acquired pneumoniaAgeInflammatory factorsT lymphocyte subsetsDiagnostic value
万方数据
维普
