Effects of Dingkundan and Letrozol on Ultrasound indicators and Inflammatory Factors in Patients with PCOS
Objective:To investigate the effects of Dingkundan combined with Letrozol on ultrasound indicators,sex hormones,and serum pro-inflammatory factors in patients with polycystic ovary syndrome(PCOS).Method:A total of 78 PCOS patients from Ruijin Maternal and Child Health Hospital from July 2020 to January 2023 were included in the study,and randomly divided into three groups:Dingkundan group(n=26),Letrozol group(n=26),and combination group(n=26).All three groups received corresponding treatment for three cycles.Ultrasound indicators such as ovarian size,follicle count,and endometrial thickness,the levels of serum sex hormones[follicle stimulating hormone(FSH),luteinizing hormone(LH),estradiol(E2),and testosterone(T)]and pro-inflammatory factors[tumor necrosis factor-α(TNF-α),C reactive protein(CRP)]were compared among three groups.Result:Before treatment,there were no statistically significant differences in ultrasound indicators(follicle count,endometrial thickness,ovarian volume),FSH,LH,E2,and T levels,as well as TNF-α and CRP levels among the three groups of patients(P>0.05).After treatment,number of follicles,endometrial thickness,and ovarian volume in the combination group were significantly better than those in the Dingkundan group and the Letrozol group,the differences were statistically significant(P<0.05).After treatment,there were no statistically significant differences in FSH and E2 levels among the three groups compared to those before treatment(P>0.05);LH and T levels in all three groups were decreased significantly compared to those before treatment,and those in the combination group were lower than those in the Dingkundan group and the Letrozol group,the differences were statistically significant(P<0.05).After treatment,the levels of TNF-α and CRP in all three groups were decreased compared to those before treatment,and those in the combination group were lower than those in the Dingkundan group and the Letrozol group,the differences were statistically significant(P<0.05).Conclusion:The combination therapy of Dingkundan and Letrozol can effectively improve ultrasound indicators,regulate sex hormone levels,and lower serum pro-inflammatory factor levels in patients with PCOS,providing a new strategy for clinical treatment of PCOS.
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