Effects of Salvianolate on Neuroendocrine Indexes,Echocardiographic Parameters and sCD146 in Patients with Heart Failure with Mid-range Ejection Fraction
Objective:To investigate the influence of Salvianolate for neuroendocrine indexes,echocardiographic parameters and soluble CD146 molecule(sCD146)of patients with heart failure with mid-range ejection fraction.Method:A total of 80 patients with heart failure of mid-range ejection fraction in Hongqi Hospital Affiliated to Mudanjiang Medical University from October 2021 to June 2023 were divided into control group and observation group by the random number table.40 patients in the control group received conventional heart failure treatment,and 40 patients in the observation group were given Salvianolate in addition to conventional treatment.The total effective rates,cardiac function indexes[cardiac output(CO),cardiac index(CI)and stroke volume(SV)],neuroendocrine indexes[aldosterone(ALD),angiotensin Ⅱ(AngⅡ)and brain natriuretic peptide(BNP)],echocardiographic parameters[E peak velocity/late diastolic phase A-peak velocity(E/A),tricuspid regurgitationmax(TRmax)and E peak velocity/averaged e'velocity(E/e')]and sCD146 before and after the treatment of two groups were compared.Result:The total effective rate of observation group was significantly higher than that of control group,the difference was statistically significant(P<0.05);the cardiac function indexes,neuroendocrine indexes,echocardiographic parameters and sCD146 of two groups before the treatment were compared,the differences were not statistically significant(P>0.05),after 1 month and 2 months of treatment,the cardiac function indexes and E/A of the observation group were significantly higher than those of the control group,and the neuroendocrine indexes,TRmax,E/e'and sCD146 were significantly lower than those of the control group,the differences were statistically significant(P<0.05).Conclusion:The application effect of Salvianolate in patients with heart failure with mid-range ejection fraction is better,and it can significantly improve the neuroendocrine indexes,echocardiographic parameters and sCD146 of patients,so its application value in atients with heart failure with mid-range ejection fraction is higher.
SalvianolateHeart failure with mid-range ejection fractionNeuroendocrineEchocardiographic parameterssCD146
万方数据
维普
