Effect of Atorvastatin on Endothelial Function and Incidence of Cardiovascular Events in Maintenance Hemodialysis Patients with Cardiovascular Disease
Objective:To investigate the effects of Atorvastatin on endothelial function and incidence of cardiovascular events in maintenance hemodialysis(MHD)patients with cardiovascular disease.Method:A total of 82 MHD patients with cardiovascular disease admitted to Nanchang People's Hospital from August 2021 to August 2023 were selected.According to random number table method,they were divided into control group and observation group,with 41 cases in each group.On the basis of MHD treatment,the control group was treated with conventional adjuvant therapy,and the observation group was treated with Atorvastatin on the basis of the control group.Vascular endothelial function[flow-mediated dilation(FMD)],cardiac function indicators[cardiac output(CO),left ventricular septum thickness(LVST)and left ventricular ejection fraction(LVEF)],inflammatory factors[interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),C reactive protein(CRP)]before and 3 months after treatment and cardiovascular events between the two groups were compared.Result:Before treatment,there were no significant differences in vascular endothelial function,cardiac function indexes and inflammatory factors between the two groups(P>0.05).After 3 months of treatment,FMD,CO,LVST and LVEF in observation group were higher than those in control group,IL-6,TNF-α and CRP were lower than those in control group,the differences were statistically significant(P<0.05).The incidence of cardiovascular events in the observation group was 4.88%,which was lower than 19.51%in the control group,the difference was statistically significant(P<0.05).Conclusion:Atorvastatin applied to MHD patients with cardiovascular disease can repair vascular endothelial function,improve cardiac function,reduce the level of inflammatory factors,and thus reduce the incidence of cardiovascular events.
万方数据
维普
