Effect of High Flow Nasal Cannula and Non-invasive Ventilation on Blood Gas Analysis Indexes and Comfort Level in Patients with AECOPD and Type Ⅱ Respiratory Failure
Objective:To investigate the clinical efficacy of high flow nasal cannula(HFNC)versus non-invasive ventilation(NIV)in the treatment of acute exacerbation of chronic obstructive pulmonary disease(AECOPD)with type Ⅱ respiratory failure(RF).Method:A total of 86 patients with AECOPD with type Ⅱ RF were selected and admitted to Ganzhou People's Hospital from January 2022 to December 2023.They were divided into two groups according to random number table method,with 43 cases in each group.The control group was treated with NIV,and the observation group was treated with HFNC.Blood gas analysis index,lung function index,inflammation level,comfort level and complications were compared between the two groups.Result:After treatment,the partial blood pressure of carbon dioxide(PaCO2)in the observation group was(40.25±4.12)mmHg,which was lower than(45.63±4.23)mmHg in the control group,arterial partial oxygen pressure(PaO2)and arterial oxygen saturation(SaO2)were(84.15±6.62)mmHg and(96.34±2.79)%,respectively,which were higher than(78.51±6.47)mmHg and(93.31±2.53)%in control group(P<0.05).After treatment,the forced vital capacity(FVC),forced expiratory volume(FEV1)and FEV1/FVC%in the observation group were(3.12±0.48)L,(2.24±0.41)L and(71.78±5.71)%,respectively,which were higher than(2.75±0.43)L,(1.89±0.35)L,(68.72±5.41)%in control group(P<0.05).After treatment,the levels of procalcitonin(PCT),interleukin-6(IL-6)and hypersensitive C reactive protein(hs-CRP)in the observation group were(0.39±0.11)μg/L,(12.28±1.24)ng/L and(8.02±1.13)mg/L,respectively,which were lower than(0.48±0.12)μg/L,(14.37±1.32)ng/L,(10.27±1.21)mg/L in the control group,the differences were statistically significant(P<0.05).The physiological,psychological,spiritual,sociocultural and environmental scores and total scores of GCQ in the observation group were(15.52±1.55),(25.63±2.34),(21.65±2.34),(27.85±2.26)and(90.65±6.58)scores,respectively,which were higher than(12.45±1.42),(22.39±2.25),(18.72±2.19),(24.14±2.19),(77.70±6.12)scores in the control group,and the incidence of complications was lower than that of the control group,the differences were statistically significant(P<0.05).Conclusion:HFNC treatment for AECOPD with type Ⅱ RF is more effective than NIV,can accelerate the normalization of blood gas indicators,promote lung function recovery,and has high comfort with fewer complications.
万方数据
维普
