Diagnostic Effect of Multi-slice Spiral CT Enhanced Scan Combined with EGFR Mutation Detection in Patients with Lung Cancer
Objective:To explore the diagnostic effect of multi-slice spiral CT(MSCT)enhanced scan combined with epidermal growth factor receptor(EGFR)mutation detection in patients with lung cancer.Method:A total of 80 patients with lung cancer(lung cancer group)and 50 patients with benign lung disease(benign lung disease group)confirmed by histopathological examination in the Second People's Hospital of Yichun City from January 2021 to January 2023 were selected as the study objects,and all of them underwent MSCT enhancement scan examination,and EGFR mutation were detected by xTAG70plex liquid chip technology.The signs of MSCT enhanced scan and EGFR mutation positive rate of the two groups were compared,and the diagnostic efficacy of MSCT enhanced scan combined with EGFR mutation detection in lung cancer was analyzed.Result:The proportion of lung tissue boundary unclear,spicule sign,vascular cluster sign,air bronchial sign and pleural indentation sign in MSCT enhanced scan sign of lung cancer group were higher than those of benign lung disease group(P<0.05).There were no significant differences in lesion location,lesion shape and internal structure between the two groups(P>0.05).The positive rate of EGFR mutation was 6.00%(3/50)in benign lung disease group and 63.75%(51/80)in lung cancer group,the positive rate of EGFR mutation in lung cancer group was higher than that in benign lung disease group(字2=42.257,P<0.05).The EGFR mutation positive rate in patients with maximum tumor diameter≥5 cm was higher than that in patients with<5 cm,the EGFR mutation positive rate in patients with stage Ⅲ and Ⅳ was higher than that in patients with stage Ⅰ and Ⅱ,the EGFR mutation positive rate in patients with low differentiation was higher than that in patients with medium and high differentiation,and the EGFR mutation positive rate in patients with lymph node metastasis was higher than that in patients without lymph node metastasis(P<0.05).There was no significant difference in the positive rate of EGFR mutation between the two groups with different pathological types of lung cancer(P>0.05).Receiver operating characteristic(ROC)curve showed that the sensitivity of MSCT enhanced scanning combined with EGFR mutation detection in the diagnosis of lung cancer was 93.7%and the specificity was 92.0%,which were higher than 78.5%,87.2%and 76.0%,78.5%of MSCT enhanced scan and EGFR mutation detection.Conclusion:MSCT enhanced scan combined with EGFR mutation detection can improve the diagnostic efficiency of lung cancer,and provide a certain reference for clinical screening,diagnosis and treatment of lung cancer.
万方数据
维普
