Clinical Efficacy Observation of Liraglutide Combined with Ticagrelor in the Treatment of Elderly Type 2 Diabetes Mellitus Patients with Coronary Heart Disease
Objective:To investigate the effect of Liraglutide combined with Ticagrelor on elderly patients with type 2 diabetes mellitus(T2DM)and coronary heart disease(CHD).Method:A total of 70 elderly patients with T2DM and CHD admitted to Wuhan Integrated Traditional Chinese and Western Medicine Orthopedic Hospital from January 2020 to January 2021 were selected as the study objects.They were divided into control group(n=35)and study group(n=35)according to random number table method.The control group was given Metformin Hydrochloride and Ticagrelor,and the study group was given Liraglutide combined with Ticagrelor.Blood glucose indexes[fasting plasma glucose(FPG),glycosylated hemoglobin(HbA1c)],cardiac function indexes[left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVEDD),early diastolic mitral valve flow velocity/late diastolic mitral valve flow velocity(E/A)],inflammation indexes[interleukin-6(IL-6),endothelin-1(ET-1),tumor necrosis factor-α(TNF-α)],vascular endothelial cell related factors[vascular lipostatin(Vaspin),growth hormone releasing peptide(Ghrelin)and nitric oxide(NO)]between the two groups before and after intervention were compared.Result:Before intervention,there were no significant differences in blood glucose indexes,cardiac function indexes,inflammation indexes and vascular endothelial cell related factors between the two groups(P>0.05).After intervention,the levels of FPG and HbA1c in the study group were lower than those in the control group,the differences were statistically significant(P<0.05).After intervention,LVEF,E/A in the study group were higher than those in the control group,and LVEDD was lower than that in the control group,the differences were statistically significant(P<0.05).After intervention,the levels of IL-6,ET-1 and TNF-α in the study group were lower than those in the control group,the differences were statistically significant(P<0.05).After intervention,the levels of Vaspin,Ghrelin and NO in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05).Conclusion:Liraglutide combined with Ticagrelor can effectively improve blood glucose level,cardiac function and vascular endothelial function,and reduce inflammation in elderly patients with T2DM and CHD.
LiraglutideTicagrelorElderly type 2 diabetes mellitusCoronary heart disease
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