Influence of Ziprasidone and Paliperidone Combined with Modified Electroconvulsive Therapy on Symptoms,Glucolipid Metabolism and Hormones Levels in Patients with Bipolar Disorder
Objective:To explore the influence of combined therapy with Ziprasidone,Paliperidone and modified electroconvulsive therapy(MECT)on symptoms,glucolipid metabolism and hormones in patients with bipolar disorder.Method:A total of 82 patients with bipolar disorder admitted between January 2021 and August 2023 in Jiangxi Mental Hospital were enrolled and divided into Ziprasidone group(41 cases)and Paliperidone group(41 cases)according to the random number table method.The Ziprasidone group was treated with Ziprasidone+MECT,while the Paliperidone group was given Paliperidone+MECT.The two groups were compared in terms of mania symptoms[Beck-Rafaelson mania scale(BRMS)],mental state[positive and negative syndrome scale(PANSS)],severity of bipolar disorder[clinical global impression scale for bipolar disorder(CGI-BP)],glucolipid metabolism[total cholesterol(TC),triglyceride(TG),fasting plasma glucose(FPG)]and hormones[cortisol(Cor),adrenocorticotropic hormone(ACTH),triiodothyronine(T3)]before and after treatment and adverse reactions during treatment.Result:After treatment,the BRMS score,scores of positive symptom,negative symptom and general psychopathology of PANSS,CGI-BP score and levels of Cor and ACTH were decreased in both groups compared to those before treatment(P<0.05),and those in the Ziprasidone group were lower than those in the Paliperidone group(P<0.05).After treatment,the levels of TC and TG in the two groups were increased compared to those before treatment(P<0.05),there were no statistical differences in TC and TG between the two groups(P>0.05).Before and after treatment,there were no statistical differences in T3 and FPG levels between the two groups(P>0.05).There was no obvious difference in adverse reaction between the two groups(12.20%vs 19.51%)(P>0.05).Conclusion:Ziprasidone+MECT for patients with bipolar disorder can relieve the mania symptoms,promote the improvement of mental state,and stabilize the glucolipid metabolism and hormones levels,and it has low adverse reactions.
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