Effects of Dihydroergotoxine on Neurologic Function,Cognitive Function and Inflammatory Factors Levels in Patients with Cerebral Small Vessel Disease Cognitive Impairment
Objective:To investigate the effect of Dihydroergocline in the treatment of cerebral small vessel disease cognitive impairment and its influence on inflammatory factors.Method:A total of 73 patients with cerebral small vessel disease cognitive impairment admitted to the Sixth People's Hospital of Nantong from April 2022 to July 2023 were selected and divided into observation group(n=37)and control group(n=36)according to random number table.Patients in both groups were treated with standard treatment for cerebral small vessel disease.The control group was given Donepezil Hydrochloride Tablets,and the observation group was given Dihydroergotoxine Methanesulfonate Sustained Release Tablets.The neurologic function[national institutes of health stroke scale(NIHSS)],mini-mental state examination(MMSE)scores,activity of daily living(ADL)score and inflammatory factors before and after treatment were compared between the two groups.The therapeutic effect and the incidence of adverse reactions were evaluated in both groups.Result:After 90 days of treatment,NIHSS in both groups were decreased,that in the observation group was lower than that in the control group,MMSE and ADL scores were increased,those in the observation group were higher than those in the control group,the differences were statistically significant(P<0.05).The total effective rate of observation group was higher than that of control group(P<0.05).After 90 days of treatment,hypersensitive C reactive protein,homocysteine and interleukin-6 were decreased in both groups,those in the observation group were lower than those in the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion:For cerebral small vessel disease cognitive impairment,the treatment effect of Dihydroergodine is satisfactory,which can significantly improve the neurologic function and cognitive function of patients,improve the ability of daily living,reduce the levels of serum inflammatory factors,and have high safety.
Cerebral small vessel diseaseCognitive impairmentDihydroergosineHypersensitive C reactive protein
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