Effect of Morita Therapy Combined with Eszopiclone on Sleep Quality and Neurotransmitter Levels in Patients with Depression and Insomnia
Objective:To investigate the effect of Morita therapy combined with Eszopiclone on sleep quality and neurotransmitter levels in patients with depression and insomnia.Method:A total of 156 patients with depression and insomnia admitted to the Sleep Department of Ganzhou Third People's Hospital from August 2020 to August 2023 were retrospectively selected as the research objects.According to the treatment plan,they were divided into drug group(n=74)and combined group(n=82).Both groups were treated with antidepressants.The drug group was treated with Eszopiclone,and the combined group was treated with Morita therapy on the basis of the drug group.The clinical efficacy,depression degree[Hamilton depression scale(HAMD)score,depression scale(CES-D)],sleep index[Pittsburgh sleep quality index(PSQI),Athens insomnia scale(AIS),total sleep time],related neurotransmitters[substance P(SP),neuropeptide Y(NPY),5-hydroxytryptamine(5-HT),γ-aminobutyric acid(γ-GABA)],life satisfaction index A(LSIA)and index of well-being(IWB)scores were compared between the two groups.Result:The total effective rate of the combined group(82.93%)was significantly higher than that of the drug group(66.22%)(P<0.05).The HAMD,CES-D,PSQI,AIS,SP and IWB of the two groups after 2 months of treatment were lower than those before treatment,and the total sleep time were longer than those before treatment,NPY,5-HT,γ-GABA and LSIA were higher than those before treatment;the HAMD,CES-D,PSQI,AIS,SP and IWB in the combined group were lower than those in the drug group,and the total sleep time was longer than that in the drug group,NPY,5-HT,γ-GABA and LSIA were higher than those in the drug group(P<0.05).Conclusion:Morita therapy combined with Eszopiclone can improve the clinical efficacy of patients with depression and insomnia,increase sleep time,improve sleep quality,regulate neurotransmitter levels,and improve life satisfaction and happiness.
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