Effect of Dapagliflozin Combined with Conventional Western Medicine Regimen in the Treatment of Patients with Chronic Heart Failure
Objective:To study the effect of Dapagliflozin combined with conventional western medicine regimen in the treatment of chronic heart failure(CHF)and its influence on patients'cardiac function,biochemical indicators and major adverse cardiovascular events(MACE).Method:A total of 70 patients with CHF admitted to Pingxiang People's Hospital from February 2022 to December 2023 were selected and divided into traditional group and study group according to envelope method,with 35 cases in each group.The traditional group was treated with conventional western medicine regimen(Metoprolol+Spironolactone+Furosemide),and the study group was treated with Dapagliflozin on the basis of the traditional group,and both groups were treated for 8 weeks.The curative effect,6 min walk test(6MWT),cardiac function[left ventricular ejection fraction(LVEF),left ventricular end-systolic volume(LVESV),cardiac output(CO),left ventricular end-systolic diameter(LVESD),stroke volume(SV)and left ventricular end-diastolic diameter(LVEDD)]and biochemical indicators[N-terminal pro-brain natriuretic peptide(NT-proBNP),cardiac troponin I(cTnI),creatine kinase MB(CK-MB),aspartate aminotransferase(AST)and blood urea nitrogen(BUN)]and the incidence of MACE were compared between the two groups.Result:The total effective rate of the study group was 94.29%,which was higher than 77.14%of the traditional group(P<0.05).After 5 and 8 weeks of treatment,6MWT in the study group were longer than those in the traditional group(P<0.05).After treatment,CO,LVEF and SV of the study group were higher than those of the traditional group,LVESV,NT-proBNP,cTnI,CK-MB,AST and BUN were lower than those of the traditional group,LVESD and LVEDD were smaller than those of the traditional group(P<0.05).The incidence of MACE in the study group was 5.71%,which was lower than 25.71%in the traditional group(P<0.05).Conclusion:Dapagliflozin combined with conventional western medicine regimen in the treatment of CHF can obviously improve patients'cardiac function,with remarkable curative effect,and can reduce the incidence of MACE.
国家科技期刊平台
NSTL
万方数据
