Study on Application of Serum TK1 Combined with CEA,CA125 and CA19-9 in Screening the Risk of Gastrointestinal Tumor
Objective:To investigate the application of serum thymidine kinase 1(TK1)combined with carcinoembryonic antigen(CEA),carbohydrate antigen 125(CA125)and carbohydrate antigen 19-9(CA19-9)in screening the risk of gastrointestinal tumor.Method:The data of 80 physical examiners who underwent gastroin testinal tumor risk screening in Pingxiang People's Hospital from January 2020 to January 2023 were analyzed retrospectively.Those detected with malignant tumors were included in the malignant tumor group(n=30),those detected with benign tumors were included in the benign tumor group(n=30),and healthy individuals were included in the healthy group(n=20).Serum TK1,CEA,CA125 and CA19-9 levels in the three groups were detected,the differences in tumor markers level among the three groups were compared,the diagnostic value of single marker and combination of above-mentioned markers in predicting malignant tumors was analyzed using the receiver operating characteristic(ROC)curve.Result:The levels of TK1,CEA,CA125 and CA19-9 in the malignant tumor group and the benign tumor group were higher than those in the healthy group(P<0.05),and tumor markers in the malignant tumor group were higher than those in the benign tumor group,the differences were statistically significant(P<0.05).The area under the curve(AUC)of TK1 for predicting malignant tumors was 0.894,sensitivity and specificity were 76.47%and 96.43%,respectively(P<0.05);the AUC of CEA for predicting malignant tumors was 0.859,sensitivity and specificity were 88.24%and 64.29%,respectively(P<0.05);the AUC of CA125 for predicting malignant tumors was 0.845,sensitivity and specificity were 68.63%and 82.14%,respectively(P<0.05);the AUC of CA19-9 for predicting malignant tumors was 0.845,sensitivity and specificity were 98.04%and 57.14%,respectively(P<0.05);the sensitivity of joint prediction was relatively high,which was 100%.Conclusion:Compared with healthy people,patients with benign and malignant tumors have elevated levels of TK1,CEA,CA125 and CA19-9,especially patients with malignant tumors.The efficacy of a single tumor marker is relatively low,and misdiagnosis are more likely to occur by false positives,the efficacy of joint detection is relatively high.
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