摘要
目的:分析多囊卵巢综合征(PCOS)患者体外受精-胚胎移植(IVF-ET)助孕结局的影响因素.方法:选取 2021 年 1 月—2022 年 12 月在赣州市妇幼保健院进行IVF-ET助孕的 91 例PCOS患者,随访 6 个月,统计患者助孕结局(临床妊娠率、未妊娠率),比较不同临床特征和不同助孕结局患者抗米勒管激素(AMH)、孕酮(P)、催乳素(PRL)、黄体生成素(LH)、睾酮(T)、雌二醇(E2)、卵泡刺激素(FSH)水平,采用logistic回归分析PCOS患者临床妊娠的影响因素.结果:91 例PCOS患者中有 68 例临床妊娠、23 例未妊娠;临床妊娠和未妊娠患者P、PRL、LH、T、年龄、PCOS病程水平比较,差异均无统计学意义(P>0.05);临床妊娠患者体重指数(BMI)低于未妊娠患者,血清AMH、E2、FSH水平均高于未妊娠患者,差异均有统计学意义(P<0.05).多因素logistic回归分析显示,AMH、E2、FSH水平降低是影响PCOS患者临床妊娠的危险因素(P<0.05).结论:AMH、E2、FSH水平降低是影响PCOS患者临床妊娠的危险因素,助孕时可通过血清AMH、E2、FSH水平预测临床妊娠.
Abstract
Objective:To analyze the influencing factors of in vitro fertilization-embryo transfer(IVF-ET)assisted pregnancy outcomes in patients with polycystic ovary syndrome(PCOS).Method:A total of 91 PCOS patients who underwent IVF-ET assisted pregnancy in Ganzhou Maternal and Child Health Hospital from January 2021 to December 2022 were selected,followed up for 6 months,and their assisted pregnancy outcomes(clinical pregnancy rate and non-pregnancy rate)were analyzed.The levels of anti-miller tube hormone(AMH),progesterone(P),prolactin(PRL),luteinizing hormone(LH),testosterone(T),estradiol(E2)and follicle stimulating hormone(FSH)in patients with different clinical characteristics and different assisted pregnancy outcomes were compared,and the influencing factors of clinical pregnancy in PCOS patients were analyzed by logistic regression.Result:Among the 91 PCOS patients,68 were clinically pregnant and 23 were not pregnant.There were no significant differences in the levels of P,PRL,LH,T,age and PCOS course between clinically pregnant and non-pregnant patients(P>0.05).Body mass index(BMI)of clinically pregnant patients was lower than that of non-pregnant patients,and serum AMH,E2 and FSH levels were higher than those of non-pregnant patients,the differences were statistically significant(P<0.05).Multiple logistic regression analysis showed that the decreased levels of AMH,E2 and FSH were risk factors for clinical pregnancy in PCOS patients(P<0.05).Conclusion:Elevated levels of AMH,E2 and FSH are protective factors affecting clinical pregnancy in PCOS patients,and clinical pregnancy can be predicted by serum AMH,E2 and FSH levels during pregnancy.
基金项目
赣州市指导性科技计划项目(GZ2021ZSF317)
国家科技期刊平台
NSTL
万方数据