Efficacy and Safety of Combined Bifidobacterium,Lactobacillus,Enterococcus and Bacillus Cereus Tablets,Live Combined with Standard Quadruple Therapy in the Treatment of Peptic Ulcer with Hp Infection
Objective:To observe the therapeutic effect and safety of adding Bifidobacterium,Lactobacillus,Enterococcus and Bacillus Cereus Tablets,Live in the basis of standard quadruple therapy in patients with peptic ulcer with helicobacter pylori(Hp)infection.Method:A total of 180 patients with peptic ulcer with Hp infection admitted to Department of Gastroenterology,Beijing Renhe Hospital from June 2021 to May 2023 were selected and divided into control group(n=90,given standard quadruple therapy)and observation group(n=90,given standard quadruple therapy combined with Combined Bifidobacterium,Lactobacillus,Enterococcus and Bacillus Cereus Tablets,Live)according to random number table method.The excellent and good rate of ulcer healing,Hp clearance rate,gastrointestinal function[motilin(MTL),D-lactic acid(D-LA),somatostatin(SS)],inflammatory factors[interleukin-10(IL-10),matrix metalloproteinase-9(MMP-9),tumor necrosis factor-α(TNF-α)],adverse reactions and recurrence rate were compared between two groups.Result:The excellent and good rate of ulcer healing and Hp clearance rate in the observation group were higher than those in the control group,the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in gastrointestinal function and inflammatory factors between two groups(P>0.05).After treatment,MTL,D-LA,MMP-9 and TNF-α in both groups were decreased,IL-10 and SS were increased,and MTL,D-LA,MMP-9 and TNF-α in the observation group were lower than those in the control group,IL-10 and SS were higher than those in the control group,the differences were statistically significant(P<0.05).There was no significant difference in adverse reactions between observation group and control group(P>0.05).The recurrence rate of the observation group was lower than that of the control group,the difference was statistically significant(P<0.05).Conclusion:Standard quadruple therapy combined with Combined Bifidobacterium,Lactobacillus,Enterococcus and Bacillus Cereus Tablets,Live for peptic ulcer with Hp infection can improve Hp clearance rate,accelerate ulcer healing process,improve gastrointestinal function,reduce inflammatory response,and reduce the risk of long-term recurrence,with high safety.
Hp infectionPeptic ulcerStandard quadruple therapyCombined Bifidobacterium,Lactobacillus,Enterococcus and Bacillus Cereus Tablets,Live
万方数据
维普
