Correlation between Serum Uric Acid,GFAP and NSE Levels and Secondary Epilepsy after Acute Cerebral Infarction
Objective:To explore the correlation between levels of serum uric acid(UA),glial fibrillary acidic protein(GFAP)and neuron-specific enolase(NSE)and secondary epilepsy after acute cerebral infarction.Method:A total of 355 patients with acute cerebral infarction admitted to Shangrao Municipal Hospital were included in the study from January 2023 to March 2024.According to the secondary epilepsy condition,they were divided into epilepsy group(n=32)and non-epilepsy group(n=323).The differences in general data,clinical characteristics,biochemical indicators and imaging indicators were compared between both groups,and logistic regression analysis was used to analyze the influencing factors of secondary epilepsy in patients with acute cerebral infarction.Pearson correlation coefficient or Spearman correlation coefficient was applied to analyze the correlation between UA,GFAP,NSE and these influencing factors.Result:The incidence rate of secondary epilepsy after acute cerebral infarction was 9.01%.There were no significant differences in gender,age,body mass index,unhealthy lifestyle and chronic history between the epilepsy group and the non-epilepsy group(P>0.05).The levels of UA,GFAP and NSE,the proportion of infarction involving cortex,score of national institutes of health stroke scale(NIHSS)and the proportion of cardiogenic cerebral infarction in epilepsy group were higher than those in non-epilepsy group,and the diameter of infarction was larger than that in non-epilepsy group,with statistical differences(P<0.05).UA,GFAP,NSE,infarction location,infarction diameter,NIHSS score and cerebral infarction classification were the influencing factors of secondary epilepsy after acute cerebral infarction(P<0.05).UA,GFAP and NSE were correlated with infarction location,infarction diameter,NIHSS score and cerebral infarction classification(P<0.05).Conclusion:Serum UA,GFAP and NSE levels after acute cerebral infarction are the influencing factors of secondary epilepsy.Early monitoring of serum UA,GFAP and NSE levels in patients with acute cerebral infarction is helpful to guide clinical diagnosis and treatment.
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