摘要
目的:探究急性脑梗死后血清尿酸(UA)、胶质纤维酸性蛋白(GFAP)和神经元特异性烯醇化酶(NSE)水平与继发癫痫的相关性.方法:选取上饶市立医院 2023 年 1 月—2024 年 3 月收治的355 例急性脑梗死患者纳入研究,根据继发癫痫情况分为癫痫组(n=32)和非癫痫组(n=323).比较两组一般资料、临床特征、生化指标、影像学指标差异,使用logistic回归分析急性脑梗死患者继发癫痫的影响因素,使用Pearson相关系数或Spearman相关系数分析UA、GFAP、NSE与这些影响因素的相关性.结果:急性脑梗死后继发癫痫发生率 9.01%;癫痫组与非癫痫组性别、年龄、体重指数、不良生活方式、慢性病史差异均无统计学意义(P>0.05),癫痫组UA、GFAP、NSE水平、梗死累及皮层占比、美国国立卫生院卒中量表(NIHSS)评分及心源性脑梗死占比均高于非癫痫组,梗死灶直径大于非癫痫组,差异均有统计学意义(P<0.05);UA、GFAP、NSE水平、梗死部位、梗死灶直径、NIHSS评分、脑梗死分型均为急性脑梗死后继发癫痫的影响因素(P<0.05);UA、GFAP、NSE与梗死部位、梗死灶直径、NIHSS评分、脑梗死分型均存在相关性(P<0.05).结论:急性脑梗死后血清UA、GFAP、NSE水平是继发癫痫的影响因素,急性脑梗死患者治疗早期监测血清UA、GFAP、NSE水平有助于指导临床诊疗.
Abstract
Objective:To explore the correlation between levels of serum uric acid(UA),glial fibrillary acidic protein(GFAP)and neuron-specific enolase(NSE)and secondary epilepsy after acute cerebral infarction.Method:A total of 355 patients with acute cerebral infarction admitted to Shangrao Municipal Hospital were included in the study from January 2023 to March 2024.According to the secondary epilepsy condition,they were divided into epilepsy group(n=32)and non-epilepsy group(n=323).The differences in general data,clinical characteristics,biochemical indicators and imaging indicators were compared between both groups,and logistic regression analysis was used to analyze the influencing factors of secondary epilepsy in patients with acute cerebral infarction.Pearson correlation coefficient or Spearman correlation coefficient was applied to analyze the correlation between UA,GFAP,NSE and these influencing factors.Result:The incidence rate of secondary epilepsy after acute cerebral infarction was 9.01%.There were no significant differences in gender,age,body mass index,unhealthy lifestyle and chronic history between the epilepsy group and the non-epilepsy group(P>0.05).The levels of UA,GFAP and NSE,the proportion of infarction involving cortex,score of national institutes of health stroke scale(NIHSS)and the proportion of cardiogenic cerebral infarction in epilepsy group were higher than those in non-epilepsy group,and the diameter of infarction was larger than that in non-epilepsy group,with statistical differences(P<0.05).UA,GFAP,NSE,infarction location,infarction diameter,NIHSS score and cerebral infarction classification were the influencing factors of secondary epilepsy after acute cerebral infarction(P<0.05).UA,GFAP and NSE were correlated with infarction location,infarction diameter,NIHSS score and cerebral infarction classification(P<0.05).Conclusion:Serum UA,GFAP and NSE levels after acute cerebral infarction are the influencing factors of secondary epilepsy.Early monitoring of serum UA,GFAP and NSE levels in patients with acute cerebral infarction is helpful to guide clinical diagnosis and treatment.
基金项目
上饶市科技计划医疗卫生项目(2023CZDX142)
维普
万方数据