Effect of Apatinib Combined with Tegafur,Gimeracil and Oteracil Potassium in the Treatment of Advanced Gastric Cancer and Its Influence on IL-6 Family Factors
Objective:To explore the effect of Apatinib combined with Tegafur,Gimeracil and Oteracil Potassiumin in the treatment of advanced gastric cancer patients and the influence on interleukin-6(IL-6)family factors.Method:A total of 90 patients with advanced gastric cancer in Liaoyang Central Hospital from April 2020 to November 2022 were divided into control group(45 cases)and observation group(45 cases)according to random number table method.The control group was treated with Tegafur,Gimeracil and Oteracil Potassium,the observation group was treated with Apatinib combined with Tegafur,Gimeracil and Oteracil Potassium.The total effective rates,various adverse reactions rates,life quality[the quality of life questionnaire core 30(QLQ-C30 score)]and IL-6 family factors[IL-6,interleukin-27(IL-27)and interleukin-31(IL-31)]before and after treatment of two groups were compared.Result:The total effective rate of observation group was significantly higher than that of control group,the difference was statistically significant(P<0.05).The various adverse reactions rates of two groups were compared,the differences were not statistically significant(P>0.05).There were no statistical significance in QLQ-C30 scores and IL-6 family factors between two groups before treatment(P>0.05);after 2 and 4 cycles of treatment,the QLQ-C30 scores of the observation group were significantly higher than those of the control group,and the IL-6 family factors were significantly lower than those of the control group,the differences were statistically significant(P<0.05).Conclusion:The effect of Apatinib combined with Tegafur,Gimeracil and Oteracil Potassium in patients with advanced gastric cancer is better,its safety is confirmed,and it can significantly improve the life quality and expression of IL-6 family factors of patients,so its application value in the patients with advanced gastric cancer is higher.
ApatinibTegafur,Gimeracil and Oteracil PotassiumAdvanced gastric cancerSafetyIL-6 family factors
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