The Therapeutic Effect of Triple Therapy on Knee Osteoarthritis and Its Impact on Serum BMP-2,Cartilage Oligomer Protein,and Inflammatory Factor Levels
Objective:To explore the therapeutic effect of Zuogui Pills,platelet-rich plasma(PRP),mesenchymal stem cell(MSCs)triple therapy on patients with knee osteoarthritis and its influence on the levels of serum bone morphogenetic protein-2(BMP-2),cartilage oligomeric matrix protein(COMP)and serum inflammatory factors[interleukin-6(IL-6),interleukin-17(IL-17),C reactive protein(CRP)].Method:A total of 98 patients with knee osteoarthritis treated in Xinyu People's Hospital from April 2022 to January 2023 were selected and divided into control group and observation group according to the random lottery method,with 49 cases in each group.The control group received conventional treatment for knee osteoarthritis,and the observation group was added with Zuogui Pills,PRP,and MSCs triple therapy on this basis.The TCM syndrome score,Lequesne functional index(Lequesne),BMP-2,COMP,Western Ontario and McMaster University Osteoarthritis Index(WOMAC)score,IL-6,IL-17,CRP levels and efficacy of two groups were compared before and after treatment.Result:After treatment,compared with the control group,the scores of TCM syndrome,Lequesne,WOMAC score,COMP,IL-6,IL-17 and CRP levels were lower in the observation group(P<0.05),and the level of BMP-2 was higher(P<0.05),and the curative effect was better(P<0.05).Conclusion:Zuogui Pills,PRP and MSCs triple therapy has good therapeutic effect,which can improve the knee function of patients more effectively,relieve the discomfort brought by the disease and improve the living levels of patients.