Effect of Human Epidermal Growth Factor Gel Combined with Dot Matrix Laser on Skin Barrier Function and Quality of Life in Patients with Acne Scar
Objective:To analyze the efficacy of Human Epidermal Growth Factor Gel combined with dot matrix laser on skin barrier function and quality of life in acne scar patients.Method:A total of 100 patients with acne scar admitted to Mianyang Hospital Affiliated to School of Medicine,University of Electronic Science and Technology of China and Mianyang Central Hospital from December 2022 to November 2023 were selected as the study objects,and they were divided into two groups according to random number table method,with 50 patients in each group.The control group was treated with conventional dot matrix laser irradiation,and the observation group was treated with Human Epidermal Growth Factor Gel on the basis of the control group.The therapeutic effect,skin barrier function,scar expression and quality of life of two groups were compared.Result:The total effective rate of the observation group was higher than that of the control group,the difference was statistically significant(P<0.05).After treatment,the pH value,α value and trans epidermal water loss(TEWL)of the lesion area in observation group were lower than those in control group,and the water content of stratum corneum was higher than that in control group,the differences were statistically significant(P<0.05).After treatment,thickness,color,vascular distribution and flexibility scores of scar in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).After treatment,the physiological function,physiological function,energy,social function,emotional function and mental health scores of the observation group were higher than those of the control group,the differences were statistically significant(P<0.05).Conclusion:The treatment regimen of Human Epidermal Growth Factor Gel combined with dot matrix laser irradiation for acne scar patients has a good therapeutic effect,which can significantly improve the skin function and scar tissue expression of patients,and contribute to improving the quality of life of patients.
Acne scarHuman Epidermal Growth Factor GelQuality of lifeDot matrix laser