首页|血清总IgE含量及特异性IgE检测在临床儿童过敏性疾病中的诊断意义

血清总IgE含量及特异性IgE检测在临床儿童过敏性疾病中的诊断意义

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目的:探究儿童过敏性疾病采用总IgE含量及特异性IgE检测的诊断意义.方法:选取2023 年 4 月—2024 年 4 月在上饶市妇幼保健院就诊的过敏性疾病儿童 96 例,采用化学发光法检测所有儿童的血清总IgE含量,采用全自动蛋白免疫印迹仪检测特异性IgE.分析儿童过敏性疾病的检测阳性结果,分析血清总IgE含量分布,分析不同年龄段儿童特异性过敏原阳性率,分析吸入性和食物性过敏性阳性率分布.结果:血清总IgE检测儿童过敏性疾病的阳性 66 例,阳性率为 68.75%;而特异性IgE检测阳性 58 例,阳性率为 60.42%;血清总IgE含量主要分布在 400~999 μg/L,占比为 31.25%,其次为3 000~4 999 μg/L,占比为 22.92%;随着年龄的增长,食物性过敏原阳性率有所下降,吸入性过敏原及食物+吸入性过敏原阳性率有所上升,食物性过敏原阳性率为 34.38%,吸入性过敏原阳性率为 13.54%,食物+吸入性过敏原阳性率为 12.50%;吸入性过敏原以户尘螨、屋尘、猫毛皮屑为主,占比分别为7.29%、5.21%、3.13%;食物性过敏原分别以鸡蛋白、牛奶、花生为主,占比分别为 13.54%、10.42%、7.29%.结论:过敏性疾病儿童的血清总IgE及特异性IgE检测阳性率较高,特异性IgE检测可查找过敏原因,低龄儿童食物性过敏原阳性率较高,高龄儿童吸入性过敏原阳性率较高.食物性过敏原分别以鸡蛋白、牛奶、花生为主,吸入性过敏原以户尘螨、屋尘、猫毛皮屑为主.
Diagnostic Significance of Serum Total IgE Content and Specific IgE Detection in Clinical Children with Allergic Diseases
Objective:To explore the diagnostic significance of serum total IgE content and specific IgE detection in children with allergic diseases.Method:Ninety-six children with allergic diseases admitted to Shangrao Maternal and Child Health Hospital from April 2023 to April 2024 were selected.The serum total IgE content of all children was detected by chemiluminescence method,and the specific IgE was detected by automatic protein immunoblotting.The positive detection results of allergic diseases in children were analyzed,the distribution of serum total IgE content was analyzed,the positive rate of specific allergens in children of different ages was analyzed,and the positive rate distribution of inhalation and food allergic was analyzed.Result:The number of positive lines of serum total IgE detected in children with allergic diseases was 66,the positive rate was 68.75%.The positive rate of specific IgE detection was 60.42%(58 cases).Serum total IgE content was mainly distributed in 400-999 μg/L(31.25%),followed by 3,000-4,999(22.92%).With the increase of age,the positive rate of food allergens descend,the positive rate of inhalation allergens and food+inhalation allergens increased,the positive rate of food allergens was 34.38%,the positive rate of inhalation allergens was 13.54%,and the positive rate of food+inhalation allergens was 12.50%.The main inhalant allergens were house dust mites,house dust and cat dander,accounting for 7.29%,5.21%and 3.13%respectively.The main food allergens were egg white,milk and peanut,accounting for 13.54%,10.42%and 7.29%respectively.Conclusion:The positive rate of serum total IgE and specific IgE detection in children with allergic diseases is higher,and specific IgE detection can find the cause of allergy.The positive rate of food allergens is higher in young children,and the positive rate of inhalation allergens is higher in elderly children.Food allergens are mainly egg white,milk and peanut,while inhalation allergens are house dust mites,house dust and cat dander.

Serum total IgE contentSpecific IgEAllergic disease in children

苏大冬、杨蓓、袁土良

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上饶市妇幼保健院检验科 江西 上饶 334000

上饶市妇幼保健院中医科 江西 上饶 334000

血清总IgE含量 特异性IgE 儿童过敏性疾病

2024

中国医学创新
中国保健协会

中国医学创新

影响因子:1.706
ISSN:1674-4985
年,卷(期):2024.21(25)