Study on the Diagnostic Performance of Plasma Inflammatory Markers Combined with OCT in Age-related Macular Degeneration
Objective:To investigate the diagnostic performance of plasma inflammatory markers combined with optical coherence tomography(OCT)in age-related macular degeneration(AMD),to improve diagnostic accuracy and timeliness.Method:A total of 52 AMD patients(52 eyes)from Soochow Lixiang Eye Hospital between January 2022 and January 2024 were selected as the observation group,and 52 healthy individuals(52 eyes)examined during the same period were selected as the control group.Both groups underwent OCT scanning and plasma inflammatory marker measurement.The results of inflammatory markers and OCT were compared between two groups,and the diagnostic efficiency of using plasma markers alone,OCT alone,and their combination were analyzed.Result:In the observation group,white blood cell(WBC)count,monocyte(MON)count,neutrophil(NEU)count,lymphocyte percentage,and neutrophil-to-lymphocyte ratio(NLR)were higher than those in the control group(P<0.05).The diagnostic results for inflammatory markers showed 49 true positives,3 false negatives,31 true negatives,and 21 false positives.For OCT,there were 44 true positives,46 true negatives,6 false positives,and 8 false negatives.The combined diagnostic results showed 49 true positives,47 true negatives,5 false positives,and 3 false negatives.The Kappa values for the three methods were 0.869,0.769 and 0.884,respectively.The sensitivity and specificity were as follows:inflammatory markers had a sensitivity of 94.23%and specificity of 59.62%;OCT had a sensitivity of 84.62%and specificity of 88.46%;the combined method had a sensitivity of 94.23%and specificity of 90.38%.Conclusion:The combination of plasma inflammatory markers and OCT demonstrates has high diagnostic performance in detecting age-related macular degeneration,effectively improving the accuracy of early diagnosis of AMD.