Objective:To investigate the effect of transcutaneous acupoint electrical stimulation on elderly cognitive dysfunction and its influence on serum β-site APP cleaving enzyme 1(BACE1),superoxide dismutase 1(SOD1)levels.Method:A total of 115 elderly patients with cognitive dysfunction admitted to Qidong People's Hospital from July 2020 to July 2023 were selected and divided into control group(n=57)and observation group(n=58)according to random number table method.The control group was given conventional drug treatment,and the observation group was given transcutaneous acupoint electrical stimulation on the basis of the control group.Cognitive function,serum factors(BACE1,SOD1)levels,intracranial arterial blood flow velocity[middle cerebral artery(MCA),basilar artery(BA),vertebral artery(VA)blood flow velocity]and daily living ability of the two groups were observed.Result:Before treatment,there were no significant differences in Montreal cognitive assessment scale(MoCA)scores,activity of daily living(ADL)scores,MCA,BA,VA blood flow velocity and the levels of SOD1,BACE1 between the two groups(P>0.05).After treatment,MoCA score,MCA,BA,VA blood flow velocity and the levels of SOD1,BACE1 in the observation group were significantly higher than those in the control group,and ADL score was significantly lower than that in the control group,the differences were statistically significant(P<0.05).Conclusion:The application of transcutaneous acupoint electrical stimulation in elderly patients with cognitive dysfunction can not only effectively improve cognitive function,increase the level of serum SOD1 and BACE1,but also improve hemodynamics and improve the ability of daily living.
关键词
认知功能障碍/老年患者/低频电刺激仪/血清因子/颅内动脉血流速度
Key words
Cognitive dysfunction/Elderly patients/Low frequency electrical stimulator/Serum factor/Intracranial arteries flow velocity
维普
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