Effect of Suhuang Zhike Capsules in the Adjuvant Treatment of Mycoplasma Pneumoniae Infection with Cough Variant Asthma
Objective:To investigate the effect of Suhuang Zhike Capsules in the adjuvant treatment of Mycoplasma pneumoniae(MP)infection with cough variant asthma(CVA)and its influence on interleukin-4(IL-4),interferon γ(IFN-γ)and C reactive protein(CRP).Method:A total of 80 patients with MP infection and CVA admitted to Ruijin Maternal and Child Health Care Hospital from January 2022 to December 2023 were included and randomly divided into western medicine group and Chinese medicine group,with 40 cases in each group.The western medicine group was given Azithromycin,Budesonide combined with Terbutaline atomization inhalation and other conventional treatment,and the Chinese medicine group was given Suhuang Zhike Capsules on the basis of the western medicine group.The clinical efficacy,duration of symptoms and signs,pulmonary function[forced vital capacity(FVC),forced expiratory volume in one second(FEV1),peak expiratory flow(PEF)],airway remodeling indicators[airway cavity area(AI),airway wall thickness(T),airway wall area(WA)]and inflammatory factors[interleukin-4(IL-4),IFN-γ,C reactive protein(CRP)]before and after treatment,and adverse reactions and CVA recurrence were compared between the two groups.Result:The total effective rate of Chinese medicine group(95.00%)was higher than that of western medicine group(80.00%),the difference was statistically significant(P<0.05).The duration of fever,cough,expectoration,choking and pulmonary rale in Chinese medicine group were shorter than those in western medicine group,the differences were statistically significant(P<0.05).After treatment,FVC,FEV1,PEF,IFN-γ were increased in both groups,and those in the Chinese medicine group were higher than those in the western medicine group,the differences were statistically significant(P<0.05).After treatment,AI,T and WA were decreased in both groups,those in the Chinese medicine group were lower than those in the control group,IL-4 and CRP were decreased,and those in the Chinese medicine group were lower than those in the western medicine group,the differences were statistically significant(P<0.05).There were no significant differences in the incidence of adverse reactions(10.00%vs 7.50%)and CVA recurrence(3.70%vs 8.33%)between the the Chinese medicine group and the western medicine group(P>0.05).Conclusion:Suhuang Zhike Capsules has a significant effect in the adjuvant treatment of MP infection with CVA,which can alleviate clinical symptoms,improve lung function,reduce airway remodeling,inhibit inflammatory response,and has high safety.
万方数据
维普
