Clinical Effect of Liraglutide Combined with Dagliprazin in the Treatment of Type 2 Diabetes Mellitus with NAFLD
Objective:To investigate the effects of Liraglutide combined with Dagliprazin on liver function,liver fat precipitation and oxidative stress in type 2 diabetes mellitus(T2DM)patients with non-alcoholic fatty liver disease(NAFLD).Method:A total of 104 patients with T2DM combined with NAFLD who were hospitalized in Chaisang District People's Hospital of Jiujiang City from January 2019 to June 2023 were selected.According to random number table method,the patients were divided into case group and control group,with 52 cases in each group.The control group was treated with Dagliprazin,and the case group was treated with Dagliprazin and Liraglutide.The changes of liver fat precipitation and oxidative stress were observed between the two groups.Result:After treatment,fasting blood glucose(FBG),glycated hemoglobin(HbA1c),insulin resistance index(HOMA-IR),total cholesterol(TC),triglycerides(TG),low-density lipoprotein cholesterol(LDL-C),alanine aminotransferase(ALT),aspartate aminotransferase(AST),glutamyl transpeptidase(GGT),alkaline phosphatase(ALP),malondialdehyde(MDA),cystatin C(Cys C),body mass index(BMI),waist circumference,controlled fat attenuation parameters,liver hardness index in both groups were lower than those before treatment,and the levels of fasting insulin(FINS),high-density lipoprotein cholesterol(HDL-C),superoxide dismutase(SOD),total antioxidant capacity(TAOC),and liver/spleen CT ratio in both groups were higher than those before treatment,the differences were statistically significant(P<0.05);after treatment,blood glucose and insulin indexes,blood lipids,liver function,oxidative stress,physical signs and liver precipitation in the case group were better than those in the control group,the differences were statistically significant(P<0.05).Although the incidence of adverse reactions in case group was lower than that in control group,but the difference was not statistically significant(P>0.05).Conclusion:Liraglutide combined with Dagliprazin can improve blood glucose and liver function,regulate oxidative stress and lipid,and reduce liver fat precipitation in T2DM patients with NAFLD,with good safety.
万方数据
维普
