Clinical Effect of Modified Huangtu Decoction Combined with Western Medicine in the Treatment of Acute Upper Gastrointestinal Hemorrhage
Objective:To investigate the clinical effect of modified Huangtu Decoction combined with Omeprazole and oral Norepinephrine in the treatment of acute upper gastrointestinal hemorrhage.Method:The medical records of 80 patients with acute upper gastrointestinal hemorrhage admitted to the Fifth Hospital of Jianqiang,Fuzhou from May 2022 to October 2023 were retrospectively analyzed,and they were divided into control group(n=38)and observation group(n=42)according to different treatment schemes.The control group was treated with Omeprazole and oral Norepinephrine,and the observation group was treated with modified Huangtu Decoction on this basis.The clinical efficacy,hemostatic effect,hemostatic time,blood pressure stabilization time,hospital stay,the levels of interleukin-1β(IL-1β),diamine oxidase(DAO),hypersensitive C reactive protein(hs-CRP)and gastrin(GAS)before and after treatment were compared between the two groups,and the occurrence of adverse reactions were recorded.Result:The total clinical effective rate of the observation group was 92.86%,which was higher than 76.32%of the control group,the difference was statistically significant(P<0.05).The success rate of hemostasis in the observation group were higher than those in the control group at 24 and 72 h of treatment,and the hemostasis time,blood pressure stabilization time were earlier than those in the control group,hospital stay was shorter than that in the control group,the differences were statistically significant(P<0.05).Compared with before treatment,the levels of serum GAS,DAO,IL-1β and hs-CRP in both groups were decreased after 7 days of treatment,and the above indexes in observation group were lower than those in control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:The application of modified Huangtu Decoction combined with Omeprazole and oral Norepinephrine in the treatment of acute upper gastrointestinal hemorrhage can significantly reduce the inflammatory indexes,quickly hemostasis,relieve the clinical symptoms of patients,shorten the treatment time,and have obvious curative effect and good safety.
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