Effects of Double Plasma Molecular Adsorption Combined with Low Displacement Plasma Exchange on CRP,IL-6 and Th1/Th2 Cytokines Levels in Patients with Acute-on-chronic Liver Failure
Objective:To investigate the effect of double plasma molecular adsorption(DPMAS)combined with low displacement plasma exchange(LPE)on acute-on-chronic liver failure(ACLF)and its influence on the levels of C reactive protein(CRP),interleukin-6(IL-6)and Th1/Th2 cytokines.Method:A total of 90 patients with ACLF admitted to the Fifth People's Hospital of Suzhou from October 2021 to October 2023 were selected and divided into observation group and control group according to random number table method,with 45 cases in each group.Patients in the control group were treated with LPE alone,and patients in the observation group were treated with DPMAS combined with LPE.The course of treatment was 2 weeks.Liver function[alanine aminotransferase(ALT),aspartate aminotransferase(AST),total bilirubin(TBIL),prothrombin activity(PTA)],inflammatory factors(CRP,IL-6),Th1/Th2 cytokines[interferon-γ(IFN-γ),interleukin-10(IL-10),tumor necrosis factor-α(TNF-α)]before and after treatment were compared between the two groups,and the occurrence of adverse reactions during treatment in the two groups were recorded.Result:After 2 weeks of treatment,ALT,AST,TBIL,CRP,IL-6,IFN-γ,TNF-α in both groups were lower than those before treatment,and those in the observation group were lower than those in the control group(P<0.05).After 2 weeks of treatment,IL-10 in both groups were increased,and that in the observation group was higher than that in the control group(P<0.05).The incidence of adverse reactions in observation group was lower than that in control group(P<0.05).Conclusion:For ACLF patients,DPMAS combined with LPE can significantly improve the liver function,reduce the levels of inflammatory factors,improve the levels of Th1/Th2 cytokines,and reduce the incidence of adverse reactions.
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