Diagnostic Value of sLAG-3,PGR Combined with Hp Antibody Detection on Early Gastric Cancer
Objective:To study the diagnostic value of soluble lymphocyte activation gene-3(sLAG-3),pepsinogen Ⅰ(PGⅠ)/pepsinogen Ⅱ(PGⅡ)ratio(PGR)combined with helicobacter pylori(Hp)antibody typing detection on early gastric cancer.Method:A total of 120 patients with early gastric cancer treated in Ganzhou Cancer Hospital from January 2020 to June 2023 were selected as the study group,and 72 patients with precancerous lesions treated in our hospital during the same period were selected as the control group for retrospective analysis.The detection of sLAG-3,PGR and Hp antibody were compared between the two groups,and the value of single and combined diagnosis of these three parameters in the diagnosis of early gastric cancer were analyzed by receiver operating characteristic(ROC)curve.At the same time,sLAG-3 and PGR of precancerous lesions and early gastric cancer patients with different Hp antibody detection results were compared.Result:sLAG-3 in the study group was higher than that in the control group,and PGR was significantly lower than that in the control group(P<0.05).The positive rates of CagA-128kD,VacA-110kD,VacA-90kD,UreA and UreB in study group were significantly higher than those in control group(P<0.05).sLAG-3 of Hp antibody positive patients were significantly higher than those of Hp antibody negative patients,and PGR was lower than that of Hp antibody negative patients,the differences were statistically significant(P<0.05).ROC curve shows that the sensitivity,specificity and cut-off value of sLAG-3 were 55.00%,76.39%and 256.37 ng/mL,respectively,the sensitivity,specificity and cut-off value of PGR were 70.00%,86.11%and 2.32,respectively,the sensitivity and specificity of Hp antibody were 77.50%and 63.89%,respectively,the sensitivity and specificity of combined diagnosis were 85.00%and 79.17%,respectively.Conclusion:sLAG-3 and PGR have high specificity in the diagnosis of early gastric cancer alone,and Hp antibody has high sensitivity,the combination of the above indexes has the highest efficiency in the diagnosis of early gastric cancer.
Soluble lymphocyte activation gene-3Pepsinogen ⅠPepsinogen ⅡHelicobacter pyloriEarly gastric cancer
万方数据
维普
