Objective:To explore the value of Doxofylline combined with Budesonide suspension for inhalation in improving lung ventilation indicators and inflammatory indicators in patients with acute exacerbation of chronic obstructive pulmonary disease.Method:A prospective study was conducted,and 100 patients with acute exacerbation of chronic obstructive pulmonary disease were selected,all of whom were admitted to the First People's Hospital of Zunyi from May 2023 to May 2024.They were divided into two groups by random number table method,with 50 cases in each group.The reference group received intravenous infusion of Doxofylline,while the study group received Budesonide suspension for inhalation combined with Doxofylline.The changes of various indicators in the two groups were observed.Result:After treatment,the partial pressure of oxygen(PaO2)and pH value levels in the study group were higher than those in the reference group,the partial pressure of carbon dioxide(PaCO2)level in the study group was lower than that in the reference group,the differences were statistically significant(P<0.05).After treatment,the forced vital capacity(FVC),forced expiratory volume in one second(FEV1),and the ratio of forced expiratory volume in one second to forced vital capacity(FEV1/FVC)in the study group were higher than those in the reference group,the differences were statistically significant(P<0.05).After treatment,the percentage of eosinophils and neutrophils in the study group were lower than those in the reference group,the differences were statistically significant(P<0.05).Conclusion:The application of Doxofylline combined with Budesonide suspension for inhalation in the treatment of patients with acute exacerbation of chronic obstructive pulmonary disease is beneficial to improve lung function and airway inflammation,with obvious effects.
关键词
慢阻肺急性加重期/多索茶碱/布地奈德/雾化吸入/肺功能/气道炎症
Key words
Acute exacerbation of chronic obstructive pulmonary disease/Doxofylline/Budesonide/Inhalation/Lung function/Airway inflammation
维普
万方数据