Application of Doxofylline Combined with Budesonide in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Objective:To explore the value of Doxofylline combined with Budesonide suspension for inhalation in improving lung ventilation indicators and inflammatory indicators in patients with acute exacerbation of chronic obstructive pulmonary disease.Method:A prospective study was conducted,and 100 patients with acute exacerbation of chronic obstructive pulmonary disease were selected,all of whom were admitted to the First People's Hospital of Zunyi from May 2023 to May 2024.They were divided into two groups by random number table method,with 50 cases in each group.The reference group received intravenous infusion of Doxofylline,while the study group received Budesonide suspension for inhalation combined with Doxofylline.The changes of various indicators in the two groups were observed.Result:After treatment,the partial pressure of oxygen(PaO2)and pH value levels in the study group were higher than those in the reference group,the partial pressure of carbon dioxide(PaCO2)level in the study group was lower than that in the reference group,the differences were statistically significant(P<0.05).After treatment,the forced vital capacity(FVC),forced expiratory volume in one second(FEV1),and the ratio of forced expiratory volume in one second to forced vital capacity(FEV1/FVC)in the study group were higher than those in the reference group,the differences were statistically significant(P<0.05).After treatment,the percentage of eosinophils and neutrophils in the study group were lower than those in the reference group,the differences were statistically significant(P<0.05).Conclusion:The application of Doxofylline combined with Budesonide suspension for inhalation in the treatment of patients with acute exacerbation of chronic obstructive pulmonary disease is beneficial to improve lung function and airway inflammation,with obvious effects.
Acute exacerbation of chronic obstructive pulmonary diseaseDoxofyllineBudesonideInhalationLung functionAirway inflammation
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维普
