Effect of Hemoperfusion on Myocardial Enzyme and Rescue Success Rate in Patients with Severe Organophosphorus Poisoning
Objective:To analyze the effect of hemoperfusion on myocardial enzyme and rescue success rate in patients with severe organophosphorus poisoning.Method:A total of 72 patients with severe organophosphorus poisoning admitted to Fengcheng People's Hospital from August 1st,2021 to November 1st,2023 were selected and divided into conventional group and observation group by random number table method,with 36 cases in each group.The conventional group was treated with Atropine Sulfate Injection and Pralidoxime Iodide,and the observation group was treated with hemoperfusion on the basis of the conventional group.Both groups were treated continuously for 3 days.The awake time,hospital stay,Glasgow coma score(GCS),cholinesterase(ChE)level,inflammatory factors[C reactive protein(CRP),interleukin-6(IL-6)],rescue success rate,myocardial enzyme[lactate dehydrogenase(LDH),creatine kinase(CK)]were compared between the two groups.Result:The awake time and hospital stay of observation group were shorter than those of conventional group(P<0.05).After treatment,GCS and ChE in both groups were increased,and GCS and ChE in observation group were higher than those in conventional group(P<0.05).After treatment,CRP and IL-6 in both groups were decreased,and CRP and IL-6 in observation group were lower than those in conventional group(P<0.05).There was no significant difference in rescue success rate between the observation group[97.22%(35/36)]and the conventional group[83.33%(30/36)](P>0.05).After treatment,LDH and CK in both groups were decreased,LDH and CK in observation group were lower than those in conventional group(P<0.05).Conclusion:Hemoperfusion is effective in the treatment of severe organophosphorus poisoning,which can effectively remove inflammatory factors,increase serum ChE level,facilitate the recovery of myocardial enzyme,and improve the rescue success rate.
万方数据
维普
