Effect of LC Combined with ERCP on Perioperative Index and Liver Function in Patients with Cholecystolithiasis and Choledocholith
Objective:To analyze the efficacy of laparoscopic cholecystectomy(LC)combined with endoscopic retrograde cholangiopancreatography(ERCP)in patients with cholecystolithiasis combined with choledocholith.Method:A total of 82 patients with cholecystolithiasis combined with choledocholith admitted to China Guihang Group 302 Hospital from May 2021 to May 2023 were selected and divided into two groups according to random number table method,with 41 cases in each group.The control group underwent LC+laparoscopic common bile duct exploration T-tube choledochotomy(LCBED),and the observation group underwent LC+ERCP,and they were followed up for 3 months.Perioperative indexes,liver function,inflammatory factors and incidence of complications were compared between the two groups.Result:The amount of blood loss during surgery in the observation group was less than that in the control group,the surgery time was longer than that in the control group,the time of getting out of bed,the time of exhaust and the time of hospitalization were shorter than those in the control group,and the incidence of complications was lower than that in the control group(P<0.05).At 1 d after surgery,interleukin-6(IL-6),C reactive protein(CRP),amylase(AMS)and tumor necrosis factor-α(TNF-α)in observation group were lower than those in control group(P<0.05).There were no significant differences in aspartate aminotransferase(AST),alanine aminotransferase(ALT)and total bilirubin(TBIL)between the two groups at 1 d after surgery(P>0.05).Conclusion:Although LC combined with ERCP has a long surgery time,it has less trauma and fewer complications,can more effectively reduce inflammation,and has no obvious damage to the liver function,which is conducive to the rapid recovery of patients with cholecystolithiasis and choledocholith,which can be popularized and applied.
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