Relationship Exploration between Vaginal Microecology Changes and GBS Infection in Late Pregnancy
Objective:To explore the relationship between vaginal microecology changes and group B streptococcus(GBS)infection in late pregnancy.Method:A total of 80 gravidas in late pregnancy with suspected GBS infection admitted to Jiujiang Maternal and Child Health Hospital from January 2022 to January 2023 were selected,40 gravidas in late pregnancy with positive of genital tract GBS detection were included in the positive group,and 40 gravidas in late pregnancy with negative genital tract GBS detection were included in the negative group.Vaginal microecology indicators(functional indicators,vaginal flora density,vaginal flora diversity,vaginal clearing degree,Nugent score)were compared between the two groups.Multivariate logistic regression was used to analyze the relationship between GBS infection and vaginal microecology changes in late pregnancy.Result:Univariate analysis showed that the positive rates of hydrogen peroxide(H2O2),leukocyte esterase(LE),sialidases(SNA)and N-acetyl-β-glucosaminidase(NAG)in the positive group were higher than those in the negative group,and the abnormal rate of pH value,vaginal clearing degree,vaginal flora density,vaginal flora diversity and BV diagnostic rate were higher than those in the negative group(P<0.05).Multivariate logistic regression analysis showed that low H2O2,high LE,high pH value,abnormal vaginal clearing degree and high Nugent score were independent risk factors for GBS infection(P<0.05).Conclusion:Vaginal microecology changes are closely related to GBS infection.Clinical evaluation of H2O2,LE,pH,vaginal clearing degree and Nugent score of gravidas in late pregnancy should be emphasized for early diagnosis and intervention of GBS infection.
Late pregnancyVaginal microecologyGroup B streptococcus
万方数据
维普
