Correlation between the Expression of ER,PR,HER-2 and Ki-67 and Pathological Complete Remission in Breast Cancer Patients after Neoadjuvant Chemotherapy
Objective:To analyze the correlation between the expression of estrogen receptor(ER),progesterone receptor(PR),human epidermal growth factor receptor-2(HER-2)and Ki67 antigen(Ki-67)and pathological complete remission(pCR)in breast cancer patients after neoadjuvant chemotherapy.Method:The clinical data of 200 breast cancer patients who received neoadjuvant chemotherapy in Jiangxi Cancer Hospital from January 2022 to December 2023 were analyzed retrospectively.According to the surgical and pathological results after neoadjuvant chemotherapy,the patients were divided into pCR group(68 cases)and non-pCR group(132 cases).Clinical data and the expression of ER,PR,HER-2 and Ki-67 in the two groups were compared.The correlation between the expression of ER,PR,HER-2 and Ki-67 and pCR was analyzed by multivariate logistic regression analysis.Result:Univariate analysis found that the proportion of clinical stage Ⅱ in pCR group was higher than that in non-PCR group,the proportions of ER and PR negative were higher than those in non-PCR group,the proportion of HER-2 positive was higher than that in non-PCR group,and the proportion of Ki-67≥20%was higher than that in non-PCR group,with statistical significance(P<0.05).Multivariate logistic regression analysis found that clinical stage Ⅲ,ER positive,PR positive,HER-2 negative and Ki-67<20%were risk factors for pCR after neoadjuvant chemotherapy for breast cancer(P<0.05).Conclusion:The expressions of ER,PR,HER-2 and Ki-67 are the influencing factors of pCR in breast cancer patients after neoadjuvant chemotherapy,which provide a basis for clinical treatment.
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