Analysis of Relationship between Cerebrospinal Fluid Proinflammatory Cytokine and Blood-brain Barrier Disruption Degree and Prognosis in Patients with Intracranial Infection after Craniotomy
Objective:To analyze the relationship between cerebrospinal fluid proinflammatory cytokine and blood-brain barrier destruction degree and prognosis in patients with intracranial infection after craniotomy.Method:The clinical data of 60 patients with intracranial infection after craniotomy in Yichun People's Hospital from June 2019 to June 2023 were retrospectively analyzed.Cerebrospinal fluid proinflammatory cytokine[high mobility group protein B-1(HMGB-1),macrophage inflammatory protein-1α(MIP-1α),γ interferon(IFN-γ),interleukin-6(IL-6)]and blood-brain barrier destruction degree[cerebrospinal fluid albumin/serum albumin ratio]were measured in all patients.According to the prognosis[Glasgow coma scale(GCS)score],the patients were divided into good prognosis group(GCS score>8 points,n=24)and poor prognosis group(GCS score≤8 points,n=36).The levels of HMGB-1,MIP-1α,IFN-γ,IL-6 and the cerebrospinal fluid albumin/serum albumin ratio were compared between the two groups.Pearson correlation coefficient was used to analyze the correlation between cerebrospinal fluid proinflammatory cytokine,blood-brain barrier destruction degree and prognosis.Receiver operator characteristic(ROC)curve was used to analyze the value of cerebrospinal fluid proinflammatory cytokine combined with blood-brain barrier destruction degree in predicting the prognosis of patients with intracranial infection after craniotomy.Result:The levels of HMGB-1,MIP-1α,IFN-γ,IL-6 and the cerebrospinal fluid albumin/serum albumin ratio in the poor prognosis group were significantly higher than those in the good prognosis group,the differences were statistically significant(P<0.05).The results of Pearson correlation coefficient analysis showed that the levels of HMGB-1,MIP-1α,IFN-γ,IL-6 and the cerebrospinal fluid albumin/serum albumin ratio were negatively correlated with the GCS scores of patients with intracranial infection after craniotomy(P<0.05).In ROC curve,the area under the curve(AUC)of HMGB-1,MIP-1α,IFN-γ and IL-6 combined with cerebrospinal fluid albumin/serum albumin ratio predicted the prognosis of patients with intracranial infection after craniotomy was 0.977,the sensitivity was 94.44%,and the specificity was 92.50%.Conclusion:In patients with intracranial infection after craniotomy,the cerebrospinal fluid proinflammatory cytokine and blood-brain barrier destruction degree is closely related to the prognosis,the prognosis of patients can be predicted by detecting their levels clinically.
Intracranial infection after craniotomyCerebrospinal fluid proinflammatory cytokineBlood-brain barrier disruption degreePrognosis
万方数据
维普
