Application Value of Reticulocyte,Serum Ferritin and VitB12 Combined Detection in Differential Diagnosis of MDS and MA
Objective:To investigate the value of reticulocyte,serum ferritin(SF)and vitamin B12(VitB12)combined detection in the differential diagnosis of myelodysplastic syndrome(MDS)and megaloblastic anemia(MA).Method:A total of 43 patients with MDS admitted to Ji'an Central People's Hospital from July 2020 to November 2023 were included in the MDS group,43 patients with MA were included in the MA group,and 43 healthy subjects who underwent physical examination in our hospital were included in the control group.The plasma reticulocyte,SF and serum VitB12 levels of the three groups were compared,and the diagnostic efficiency of the three indicators alone or combined in MDS was analyzed by receiver operating characteristic(ROC)curve.Result:The levels of reticulocyte hemoglobin(Ret-He),immature reticulocyte fraction(IRF),medium fluorescence intensity reticulocyte ratio(MFR)and high fluorescence intensity reticulocyte ratio(HFR)in MDS group and MA group were higher than those in control group,the differences were statistically significant(P<0.05);the low fluorescence intensity reticulocyte ratio(LFR)in MDS and MA group was lower than that in control group(P<0.05).there were no significant differences in IRF,LFR,MFR and HFR levels between the two groups(P>0.05);the level of Ret-He in MDS group was lower than that in MA group,the difference was statistically significant(P<0.05);SF level in MDS group and MA group was higher than that in control group,the differences were statistically significant(P<0.05);the serum VitB12 level in MDS group was higher than that in control group,and the serum VitB12 level in MA group was lower than that in control group,the differences were statistically significant(P<0.05);the levels of SF and VitB12 in MDS group were higher than those in MA group,the differences were statistically significant(P<0.05).In the diagnosis of MDS,the area under ROC curve of Ret-He combined with SF and VitB12 was 0.942,which was higher than 0.755,0.813 and 0.830 under the curve of the three indexes alone,the differences were statistically significant(P<0.05).Conclusion:Reticulocyte combined with SF and VitB12 has certain value in guiding the diagnosis of MDS,the SF and VitB12 of MDS are higher than MA,and the Ret-He is lower than MA,which can be used as an important reference index for clinical diagnosis.
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