Analysis of Pathogenic Bacteria Detection Characteristics and Drug Resistance in Patients with Hematological Malignant Tumors Complicated with Severe Pulmonary Infection
Objective:To explore the distribution characteristics and drug resistance of pathogenic bacteria in patients with hematologic malignancies complicated with severe pulmonary infections.Method:A prospective study was conducted on 209 patients with hematological malignancies complicated with severe pulmonary infections admitted to Jinjiang Hospital from October 2019 to October 2022.Sputum samples were collected for bacterial culture and drug sensitivity testing to investigate the detection of pathogenic bacteria and drug resistance in the 209 patients.Result:A total of 218 strains of pathogenic bacteria were isolated from 209 patients with hematological malignancies complicated with severe pulmonary infections,of which 116 strains were detected as Gram negative bacteria,accounting for 53.21%(116/218);46 strains(21.10%)of Escherichia coli,35 strains(16.06%)of Acinetobacter baumannii,17 strains(7.80%)of Klebsiella pneumoniae,and 14 strains(6.42%)of Pseudomonas aeruginosa were most common;a total of 89 strains of Gram positive bacteria were detected,accounting for 40.83%(89/218),with 41 strains(18.81%)of Enterococcus faecalis,26 strains(11.93%)of Staphylococcus aureus,and 18 strains(8.26%)of Streptococcus pneumoniae being common;a total of 13 fungi were detected,accounting for 5.96%(13/218);the main Gram-negative bacteria resistance rate of Amikacin(AMK),Ceftriaxone(CFZ),Ceftriaxone(CRO),Ampicillin(AMP),Cefuroxime(CXM),Aztreonam(ATM),Ceftazidime(CAZ),Ciprofloxacin(CIP),Sulfamethoxazole-Trimethoprim(SMZ-TMP),Levofloxacin(LVX),and to Etapenem(ETP),Gentamicin(GEN),Tobramycin(TOB),Imipenem(IPM),Cefepime(FEP)were high,the resistance rates of Tetracycline(TE),Cefoperazone(CFP),and Meropenem(MEM)were low;the main Gram positive bacteria resistance rate of TE,CIP,gentamicin(GM),Penicillin(PEN),LVX,Oxacillin(OX),AMP,Clindamycin(CM),and Moxifloxacin(MXF)were high,but resistance rate of Nitrofurantoin(NFT),Vancomycin(VAN),Rifampicin(RIF),Tigecycline(TGC),Teicoplanin(TEC),and Linezolid(LNZ)were low.Conclusion:Gram negative bacteria are the main pathogens causing infections in patients with hematologic malignancies complicated by severe pulmonary infections,and the drug resistance of various pathogens is at a high level.Therefore,high attention should be paid to this in clinical practice.
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