Application of CDRS Combined with Advanced Glycation End Product Test in Screening Diabetes in Physical Examination Population
Objective:To explore the application value of Chinese diabetes risk score(CDRS)combined with advanced glycation end product(AGE)test in diabetes screening.Method:A total of 82 patients who underwent physical examination in Pingxiang People's Hospital from January 2022 to October 2023 were selected as the study objects.All subjects underwent CDRS assessment,AGE test and oral glucose tolerance test(OGTT).Using OGTT as the gold standard,CDRS score,AGE test results and their combined diagnosis results were tested for consistency.According to the gold standard diagnosis results,82 patients were divided into diabetes group and non-diabetes group,and the CDRS scores and AGE test results of the two groups were compared.Receiver operating characteristics(ROC)curve was used to analyze the clinical value of CDRS score,AGE test and their combination in the diagnosis of diabetes.Result:The gold standard diagnosis results showed that 22 of the 82 physical examination subjects were diagnosed as diabetes,the CDRS score results showed that 13 physical examination subjects were at high risk of diabetes,the AGE diagnosis results showed that 11 physical examination subjects were at high risk of diabetes,and the combined diagnosis results showed that 21 physical examination subjects were at high risk of diabetes.The accuracy,sensitivity and negative predictive value of combined diagnosis were higher than those of CDRS score and AGE test diagnosis alone(P<0.05).Consistency test results showed that Kappa value of combined diagnosis was 0.905,which was higher than 0.607 and 0.594 of CDRS score and AGE test diagnosis alone.The CDRS scores and AGE values in diabetic group were higher than those in non-diabetic group(P<0.05).ROC curve results showed that the area under the curve(AUC)of combined diagnosis predicted diabetes was 0.898,which was higher than 0.864 and 0.755 of CDRS score and AGE test.Conclusion:CDRS score combined with AGE test has a higher accuracy in diabetes screening in physical examination population,and its clinical prediction value is higher than that of CDRS score and AGE test diagnosis alone.
Chinese diabetes risk scoreAdvanced glycation end productDiabetes screeningPhysical examination
万方数据
维普
