Objective:To investigate the effect of modified Danggui Yinzi combined with Olopatadine Hydrochloride in the treatment of patients with chronic urticaria (CU).Method:A total of 60 patients with CU admitted to Guixi Traditional Chinese Medicine Hospital from January 2021 to January 2023 were divided into two groups by random number table method,with 30 cases in each group.Both groups were treated with Olopatadine Hydrochloride Tablets,and the observation group was add modified Danggui Yinzi for treatment.Both groups were treated continuously for 4 weeks.The treatment effect,symptom and sign scores,serological indexes,CU activity and quality of life,incidence of adverse reaction and recurrence rate were compared between the two groups.Result:After treatment,the levels of interleukin-2 (IL-2) and interferon-γ (IFN-γ) in the observation group were higher than those in the control group,and the symptom and sign scores,dermatology life quality index (DLQI) scores,urticaria activity score (UAS) and the levels of interleukin-4 (IL-4) and immunoglobulin E (IgE) were lower than those in the control group,the differences were statistically significant (P<0.05).The total effective rate of the observation group was higher than that of the control group,and the recurrence rate was lower than that of the control group,the differences were statistically significant (P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05).Conclusion:The application of modified Danggui Yinzi combined with Olopatadine Hydrochloride in the treatment of patients with CU can improve the clinical symptoms and signs,reduce the recurrence,improve the quality of life,regulate immune-related factors,and have good safety.
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