Effect of Esomeprazole in Patients with Hp Positive Gastric Ulcer and Influence for Morphology of Gastric Mucosa
Objective:To investigate the effect of Esomeprazole in patients with Helicobacter pylori (Hp) positive gastric ulcer and influence for morphology of gastric mucosa.Method:A total of 80 patients with Hp positive gastric ulcer from the First Affiliated Hospital of Xiamen University from January 2022 to March 2023 were divided into control group and observation group according to random number table method,with 40 cases in each group.Both groups were treated with quadruple therapy,with the control group receiving Omeprazole and the observation group receiving Esomeprazole.The total effective rates for gastric ulcer,improvement time of symptoms and signs,Hp eradication rates,adverse reaction rates,pepsinogens[serum pepsinogen Ⅰ (PGⅠ) and pepsinogen Ⅱ (PGⅡ)]and morphology indexes scores of gastric mucosa before and after the treatment of two groups were compared.Result:The total effective rate of gastric ulcer treatment in the observation group was higher than that in the control group,the improvement time of symptoms and signs were earlier,the eradication rate of Hp was higher than that in the control group,and the incidence of adverse reactions was lower than that in the control group (P<0.05).After 1 week and 2 weeks of treatment,the PGⅠ and PGⅡ levels in two groups were lower than those before treatment,and those of the observation group were lower than those of the control group (P<0.05).After 8 weeks of treatment,the scores of gastric mucosa morphological indexes in both groups were lower than those before treatment,and those of the observation group were lower than those of the control group (P<0.05).Conclusion:Esomeprazole has good efficacy and safety in patients with Hp positive gastric ulcer,and can significantly improve gastric mucosa morphology.
EsomeprazoleHp infectionGastric ulcerMorphology of gastric mucosa
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