Effect of Different Statins Combined with Clopidogrel on Coronary Heart Disease Patients with Hyperlipidemia
Objective:To study the effects of different statins combined with Clopidogrel on coronary heart disease (CHD) patients with hyperlipidemia.Method:A total of 80 CHD patients with hyperlipidemia treated in Jiangxi Fifth People's Hospital from January 2021 to December 2023 were selected and divided into Rosuvastatin (trade name:Crestor) group (n=40) and Atorvastatin (trade name:Lipitor) group (n=40) according to the odd-even date of treatment.The Crestor group was treated with Rosuvastatin and Clopidogrel.The Lipitor group was treated with Atorvastatin combined with Clopidogrel.Both groups were treated continuously for 2 months.Carotid artery flow dynamics indexes,lipid metabolism,cardiac function and clinical efficacy of the two groups were compared before treatment and 2 months after treatment,and the occurrence of major adverse cardiovascular events (MACE)between the two groups were recorded. Result:After 2 months of treatment,the carotid internal diameter,maximum and minimum blood flow velocity in Crestor group were higher than those in Lipitor group,and the resistance index was lower than that in Lipitor group,with statistical significance (P<0.05). After 2 months of treatment,there were no statistically significant differences in low density lipoprotein cholesterol (LDL-C),total cholesterol (TC) and triacylglycerol (TG) between the two groups (P>0.05),but high density lipoprotein cholesterol (HDL-C) in the Crestor group was higher than that in the Lipitor group (P<0.05). There were no significant differences in left ventricular end-systolic diameter (LVESD) and ejection left ventricular ejection fraction (LVEF) between the two groups before treatment (P>0.05). After 2 months of treatment,the LVESD of Crestor group was higher than that of Lipitor group,and LVEF was lower than that of Lipitor group,the differences were statistically significant (P<0.05). The total incidence of MACE in Crestor group was 10.00％,which was lower than 17.50％ in Lipitor group,and the total effective rate was 85.00％ in Crestor group,which was higher than 72.50％ in Lipitor group,but the differences were not statistically significant (P>0.05). Conclusion:Rosuvastatin combined with Clopidogrel has a significant clinical effect in the treatment of CHD patients with hyperlipidemia,which can improve the indexes of carotid blood flow and lipid metabolism,promote the recovery of cardiac function indexes,and reduce the incidence of MACE.
万方数据
维普
