Relationship between AR and Ki-67 Expression Levels and Ultrasonic Features of Triple-negative Breast Cancer
Objective:To explore the relationship between androgen receptor (AR) and Ki-67 expression levels and ultrasonic features of triple-negative breast cancer.Method:A total of 92 patients with triple-negative breast cancer who were treated in First People's Hospital of Fuzhou from May 2021 to April 2023 were retrospectively selected.All patients underwent ultrasound examination,and the expression of Ki-67 and AR were detected by immunohistochemical two-step method.The pathological features of Ki-67,AR positive expression triple-negative breast cancer patients and the ultrasound characteristics of AR positive expression and different expression levels of Ki-67 triple-negative breast cancer patients were compared.Result:The positive expression rates of Ki-67 and AR in triple-negative breast cancer were 90.22％ (83/92) and 35.87％ (33/92),respectively.The proportion of stage Ⅲ and Ⅳ in Ki-67 positive patients was higher than that in negative patients,and the proportion of stage Ⅰ and Ⅱ in AR positive patients was higher than that in negative patients,the differences were statistically significant (P<0.05).There were no significant differences in age,tumor site and maximum tumor diameter among patients with different Ki-67 and AR expression (P>0.05).The proportions of marginal burr without angulation and blood flow signal grade 0 and 1 in AR positive patients were higher than those in negative patients,the differences were statistically significant (P<0.05).The proportion of marginal burr angulation,irregular morphology,calcification,posterior echo attenuation,non-hypoechoic internal echo and blood flow signal grade 2 and 3 in Ki-67 high expression group were higher than those in low expression group (P<0.05).Conclusion:In triple-negative breast cancer patients with AR positive expression,the proportion of marginal burr without angulation and blood flow signal grade 0 and 1 are high.In triple-negative breast cancer patients with high Ki-67 expression,the proportion of marginal burr angulation,irregular morphology,calcification,posterior echo attenuation,non-hypoechoic internal echo and blood flow signal grade 2 and 3 are high.
Androgen receptorKi-67Triple-negative breast cancerUltrasonic characteristics
万方数据
维普
