AR及Ki-67表达水平与三阴性乳腺癌超声特征的关系

Relationship between AR and Ki-67 Expression Levels and Ultrasonic Features of Triple-negative Breast Cancer

胡艳 ¹邹丽 ¹邓志坚¹

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作者信息

1. 抚州市第一人民医院病理科江西抚州 344000
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摘要

目的:探究雄性激素受体(AR)及Ki-67表达水平与三阴性乳腺癌超声特征的关系.方法:回顾性选取2021年5月—2023年4月在抚州市第一人民医院进行治疗的三阴性乳腺癌患者92例.所有患者均行超声检查,并采用免疫组化二步法检测Ki-67及AR的表达情况.比较Ki-67、AR阳性表达三阴性乳腺癌患者的临床参数、AR阳性表达及不同表达水平Ki-67三阴性乳腺癌患者的超声特征.结果:Ki-67及AR在三阴性乳腺癌中的阳性表达率分别为90.22％(83/92)、35.87％(33/92);Ki-67阳性患者的Ⅲ、Ⅳ期比例高于阴性患者,AR阳性患者Ⅰ、Ⅱ期比例高于阴性患者,差异均有统计学意义(P<0.05);不同Ki-67、AR表达患者的年龄、肿瘤部位、肿瘤最大直径比较,差异均无统计学意义(P>0.05);AR阳性患者边缘毛刺无成角和血流信号0、1级比例均高于阴性患者,差异均有统计学意义(P<0.05);Ki-67高表达组边缘毛刺成角、形态不规则、钙化、后方回声衰减、内部回声非低回声及血流信号2、3级比例均高于低表达组(P<0.05).结论:AR阳性表达的三阴性乳腺癌患者,边缘毛刺无成角及血流信号0、1级的比例高,Ki-67高表达的三阴性乳腺癌患者,边缘毛刺成角、形态不规则、钙化、后方回声衰减、内部回声非低回声及血流信号2、3级比例高.

Abstract

Objective:To explore the relationship between androgen receptor (AR) and Ki-67 expression levels and ultrasonic features of triple-negative breast cancer.Method:A total of 92 patients with triple-negative breast cancer who were treated in First People's Hospital of Fuzhou from May 2021 to April 2023 were retrospectively selected.All patients underwent ultrasound examination,and the expression of Ki-67 and AR were detected by immunohistochemical two-step method.The pathological features of Ki-67,AR positive expression triple-negative breast cancer patients and the ultrasound characteristics of AR positive expression and different expression levels of Ki-67 triple-negative breast cancer patients were compared.Result:The positive expression rates of Ki-67 and AR in triple-negative breast cancer were 90.22％ (83/92) and 35.87％ (33/92),respectively.The proportion of stage Ⅲ and Ⅳ in Ki-67 positive patients was higher than that in negative patients,and the proportion of stage Ⅰ and Ⅱ in AR positive patients was higher than that in negative patients,the differences were statistically significant (P<0.05).There were no significant differences in age,tumor site and maximum tumor diameter among patients with different Ki-67 and AR expression (P>0.05).The proportions of marginal burr without angulation and blood flow signal grade 0 and 1 in AR positive patients were higher than those in negative patients,the differences were statistically significant (P<0.05).The proportion of marginal burr angulation,irregular morphology,calcification,posterior echo attenuation,non-hypoechoic internal echo and blood flow signal grade 2 and 3 in Ki-67 high expression group were higher than those in low expression group (P<0.05).Conclusion:In triple-negative breast cancer patients with AR positive expression,the proportion of marginal burr without angulation and blood flow signal grade 0 and 1 are high.In triple-negative breast cancer patients with high Ki-67 expression,the proportion of marginal burr angulation,irregular morphology,calcification,posterior echo attenuation,non-hypoechoic internal echo and blood flow signal grade 2 and 3 are high.

关键词

雄性激素受体/Ki-67/三阴性乳腺癌/超声特征

Key words

Androgen receptor/Ki-67/Triple-negative breast cancer/Ultrasonic characteristics

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出版年

2024

中国医学创新

中国保健协会

中国医学创新

影响因子：1.706

ISSN：1674-4985

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