Effects of Transcutaneous Electrical Acupoint Stimulation on Cognitive Function and Serum S100β Protein and SIRT1 Levels in Elderly Patients after Total Hip Arthroplasty
Objective:To investigate the effects of transcutaneous electrical acupoint stimulation (TEAS) on cognitive function and serum S100β protein and sirtuin 1 (SIRT1) levels in elderly patients after total hip arthroplasty. Method:A total of 100 elderly patients with total hip arthroplasty admitted to the Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine from May 2022 to December 2023 were randomly divided into electric stimulation group and false stimulation group,with 50 cases in each group. Before anesthesia induction,the electrical stimulation group was given electrical stimulation through both Neiguan and Zusanli points;in the false stimulation group,one electrode was attached to each side of Neiguan and Zusanli,but the power was not connected. The serum levels of S100β protein and SIRT1 and the incidence of postoperative cognitive dysfunction (POCD) were compared between the two groups. Result:Before surgery,there were no significant differences in serum S100β protein and SIRT1 levels between two groups (P>0.05). After surgery,serum S100β protein and serum SIRT1 levels in electrical stimulation group were lower than those in false stimulation group,the differences were statistically significant (P<0.05). On the 1 d after surgery,there was no significant difference in the incidence of POCD between the two groups (P>0.05). On the 7 d after surgery,the incidence of POCD in the electrical stimulation group was 14.0％,which was lower than 32.0％ in the false stimulation group,the difference was statistically significant (P<0.05). Conclusion:TEAS can inhibit the increase of serum S100β protein and increase the level of serum SIRT1 protein after total hip replacement in elderly patients,and also decrease the occurrence of POCD.
Elderly patientsPostoperative cognitive dysfunctionTranscutaneous electrical acupoint stimulationS100β protein
万方数据
维普
