Effect of Tropisetron Combined with Sufentanil Intravenous Controlled Analgesia on Elderly Patients with Knee Replacement
Objective:To explore the effect of Tropisetron combined with Sufentanil intravenous controlled analgesia in elderly patients with knee replacement. Method:A total of 82 elderly patients with knee replacement treated in Linyi Mental Health Center from December 2021 to December 2023 were selected as the study objects,and they were divided into control group and observation group by random number table method,with 41 cases in each group. The control group was given Sufentanil intravenous controlled analgesia after surgery,and the observation group was given Tropisetron combined with Sufentanil intravenous controlled analgesia after surgery. Postoperative cognitive function[mini-mental state examination (MMSE)],analgesia score[numeric rating scale (NRS)],inflammatory response[interleukin-6 (IL-6),interleukin-10 (IL-10),tumor necrosis factor-α (TNF-α)],gastrointestinal hormones[gastrin (GAS),motilin (MTL),vasoactive intestinal peptide (VIP)]and the occurrence of adverse reactions were compared between the two groups. Result:At 72 h and 7 d after surgery,MMSE scores in observation group were higher than those in control group,and the incidence of cognitive impairment within 7 d was lower than that in control group,the differences were statistically significant (P<0.05). At 1,12 and 24 h after surgery,NRS scores in the observation group were lower than those in the control group,the differences were statistically significant (P<0.05). Before anesthesia induction (T0),there were no significant differences in levels of IL-6,IL-10 and TNF-α between the two groups (P>0.05). After surgery (T1),6 h after surgery (T2) and 24 h after surgery (T3),levels of IL-6,IL-10 and TNF-α in two groups were higher than those T0,while levels of IL-6 and TNF-α in observation group were lower than those in control group,and levels of IL-10 were higher than those in control group,the differences were statistically significant (P<0.05). Before surgery,there were no significant differences in levels of GAS,MTL and VIP between the two groups (P>0.05). On the 1,3 d after surgery,levels of GAS and MTL in both groups were lower than those before surgery,levels of VIP were higher than those before surgery,and levels of GAS and MTL in observation group were higher than those in control group,levels of VIP were lower than those in control group,the differences were statistically significant (P<0.05). Conclusion:Tropisetron combined with Sufentanil intravenous controlled analgesia can alleviate inflammatory reactions,enhance analgesic effects,reduce the incidence of cognitive impairment,improve gastrointestinal function,and reduce adverse reactions in patients undergoing knee replacement.
TropisetronSufentanilIntravenous controlled analgesiaElderly patientsKnee replacementCognitive function
万方数据
维普
