Effect of Xiyanping Injection Combined with Budesonide Atomization Inhalation in the Treatment of Mycoplasmal Pneumoniae Pneumonia in Children and Its Influence on the Levels of IL-6 and TNF-α
Objective:To explore the value of Xiyanping Injection combined with Budesonide atomization inhalation in the treatment of children with Mycoplasmal pneumoniae pneumonia. Method:A total of 103 children with Mycoplasmal pneumoniae pneumonia who received treatment in Maternity & Child Care Center of Xinyu from January 2022 to December 2023 were selected as the study objects,and were divided into control group (n=51,given Budesonide atomization inhalation therapy) and study group (n=52,combined with Xiyanping Injection on the basis of control group) by random number table method. At the same time,both groups were given macrolides antibiotic for anti-infection. The clinical efficacy,inflammatory factors,immune factors and adverse reactions were compared between the two groups. Result:The total effective rate of the study group (96.15％) was higher than that of the control group (84.31％),the difference was statistically significant (x2=4.118,P=0.042). After treatment,the levels of hypersensitive C reactive protein (hs-CRP),interleukin-6 (IL-6),tumor necrosis factor-α (TNF-α) and CD8+in the study group were lower than those in the control group,and CD4+was higher than that in the control group,the differences were statistically significant (P<0.05). There was no significant difference in the incidence of adverse reactions between the study group (3.85％) and the control group (9.80％) (x2=1.443,P=0.230). Conclusion:Xiyanping Injection combined with Budesonide atomization inhalation therapy for children with Mycoplasmal pneumoniae pneumonia is beneficial to improve the levels of inflammatory factors and immune factors,improve the clinical efficacy,and have high safety.
万方数据
维普
