Follow-up Observation on the Effects of Neonatal Punctate White Matter Lesions on the Long-term Neurological Function of Children
Objective:To investigate the effect of punctate white matter lesions on neonatal long-term nerve function. Method:Thirty-three newborns born in the Affiliated Hospital of Zunyi Medical University from January 2012 to June 2013 who were clinically diagnosed with hypoxic-ischemic encephalopathy 3 to 7 days after birth and with punctate white matter lesions by MRI examination located in the optic radiation or optic center were selected as the observation group,and another 20 healthy newborns in the same period were selected as the control group. Both groups were followed up eight years later to assess neurological and visual function. Result:In the initial MRI examination of the observation group,9 cases (27.3％) had lesions located on the left side of the optic radiation or optic center,11 cases (33.3％) on the right side,and 13 cases (39.4％) had lesions on both sides. After 8 years of follow-up observation group,7 cases completed MRI examination,and 1 case saw enlargement of left lateral ventricle occipital angle,a small number of degenerative lesions were found in the right side of the brain in 1 case,the other 5 cases had no obvious abnormal lesions on MRI. After 8 years of follow-up,there was no statistically significant difference in visual function between the observation group and the control group (P>0.05). The Wechsler intelligence scale for children-Ⅴ (WISC-Ⅴ) score of the observation group was (96.97±10.66) points,which was lower than (105.42±9.24) points of the control group,the difference was statistically significant (t=-3.120,P=0.003). The number of lesions in the observation group was not correlated with visual function (P>0.05),but was negatively correlated with WISC-Ⅴ score (rs=-0.499,P=0.003). Conclusion:Visual radiation or punctate white matter lesions in the visual center does not affect children's visual function,but may affect children's intellectual function.
NewbornHypoxic ischemic encephalopathyPunctate white matter lesionsLong term prognosis
万方数据
维普
